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Results for "

EEF2

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

2

Recombinant Proteins

12

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110096
    A-484954
    Maximum Cited Publications
    7 Publications Verification

    		 CaMK Autophagy Cancer
    A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC50 of 280 nM.
    A-484954
  • HY-126396
    Sordarin sodium

    		Antibiotic CaMK Fungal Infection
    Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity [2].
    Sordarin sodium
  • HY-100576
    NH125
    2 Publications Verification

    		 CaMK Autophagy Bacterial Fungal Virus Protease Infection Cancer
    NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes [2].
    NH125
  • HY-124447
    BTYNB

    		IGF-1R c-Myc Apoptosis TGF-beta/Smad Cancer
    BTYNB is a structure-specific nucleic acid binder and IGF2BP1 inhibitor (with an IC50 of 5 μM against hBTYNB). BTYNB disrupts the IGF2BP1-RNA interaction and blocks its binding to oncogenic mRNAs such as c-Myc, MDM2, PD-L1. BTYNB completely blocks the INHBA-Smad2/3 pathway, disrupts the MYCN/IGF2BP1 loop, and thereby induces apoptosis and cell cycle arrest, effectively inhibiting the proliferation and survival of cancer cells. In addition, BTYNB acts as an immune activator and tumor microenvironment modulator, enhances T cell-mediated tumor killing, and produces significant synergistic effects with inhibitors of PD-1, BRD and BIRC5. BTYNB can be used in relevant research on various malignant tumors including ovarian cancer, neuroblastoma, leukemia and melanoma [2] .
    BTYNB
  • HY-146324
    PROTAC eEF2K degrader-1

    		PROTACs Apoptosis CaMK Cancer
    PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation .
    PROTAC eEF2K degrader-1
  • HY-117684
    Cabamiquine
    1 Publications Verification

    DDD107498; DDD-498; M5717

    		 Parasite CaMK Infection
    Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2 .
    Cabamiquine
  • HY-117684A
    Cabamiquine succinate
    1 Publications Verification

    DDD107498 succinate; DDD-498 succinate; M5717 succinate

    		 Parasite CaMK Infection
    Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2 .
    Cabamiquine succinate
  • HY-120904
    AMPK-IN-1

    		AMPK Metabolic Disease
    AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way [2] .
    AMPK-IN-1
  • HY-RS04180
    EEF2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EEF2 Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EEF2 Human Pre-designed siRNA Set A
    EEF2 Human Pre-designed siRNA Set A
  • HY-RS20725
    Eef2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Eef2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eef2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Eef2 Mouse Pre-designed siRNA Set A
    Eef2 Mouse Pre-designed siRNA Set A
  • HY-RS27237
    Eef2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Eef2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Eef2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Eef2 Rat Pre-designed siRNA Set A
    Eef2 Rat Pre-designed siRNA Set A
  • HY-112393
    TX-1918

    		HIV Src PKA PKC Infection
    TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM) [2].
    TX-1918
  • HY-177720
    eEF2K degrader-2

    		Molecular Glues CaMK Apoptosis Cancer
    eEF2K degrader-2 (Compound C1) is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer .
    eEF2K degrader-2
  • HY-121828
    TX-1123

    		Src CaMK PKA EGFR PKC COX Cancer
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer [2].
    TX-1123
  • HY-123024
    Cefatrizine

    BL-S-640; SK&F 60771

    		 Apoptosis Bacterial Antibiotic Infection Cancer
    Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection [2].
    Cefatrizine
  • HY-RS04181
    EEF2K Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EEF2K Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2K gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EEF2K Human Pre-designed siRNA Set A
    EEF2K Human Pre-designed siRNA Set A
  • HY-RS26516
    Eef2k Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Eef2k Rat Pre-designed siRNA Set A contains three designed siRNAs for Eef2k gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Eef2k Rat Pre-designed siRNA Set A
    Eef2k Rat Pre-designed siRNA Set A
  • HY-176149
    Fluoxetine-Conjugated Platinum(IV) prodrug-1

    		CaMK MMP AMPK Apoptosis Autophagy Cancer
    Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) is an eEF2K inhibitor. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits cancer cell proliferation, induces DNA damage, cell cycle arrest at S phase and apoptosis. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces ROS accumulation and mitochondrial dysfunction. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits TNBC cell migration and invasion by inhibiting MMP-2 activity. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces autophagy in TNBC cells by activating AMPK. Fluoxetine-Conjugated Platinum(IV) prodrug-1 has antitumor activity and activates immunosuppression in the 4T1-Luc mouse model. Fluoxetine-Conjugated Platinum(IV) prodrug-1 can be used in triple-negative breast cancer (TNBC) research .
    Fluoxetine-Conjugated Platinum(IV) prodrug-1
  • HY-RS20013
    Eef2k Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Eef2k Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eef2k gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Eef2k Mouse Pre-designed siRNA Set A
    Eef2k Mouse Pre-designed siRNA Set A
  • HY-181506
    TYMJ-01

    		Fluorescent Dye Molecular Glues CaMK c-Myc Bcl-2 Family Cadherin Cancer
    TYMJ-01 is a fluorescent probe and eEF2K degrader. TYMJ-01 induces dose-dependent and specific degradation of eEF2K via the ubiquitin-proteasome pathway, with a DC50 of 82 nM. TYMJ-01 inhibits the proliferation, migration and invasion of triple-negative breast cancer cells. TYMJ-01 enables dynamic fluorescent imaging of eEF2K degradation in triple-negative breast cancer cells; it enhances the anti-tumor activity of Paclitaxel (HY-B0015). TYMJ-01 can be used for the research of triple-negative breast cancer .
    TYMJ-01

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