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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
EEF2
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "EEF2" in MCE Product Catalog:
9
3
3 Cited Publications
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes [2].
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1 Cited Publications
Target:
Research Areas:
Epiblastin A is an ATP-competitive casein kinase 1 (CK1) inhibitor that inhibits CK1α, CK1δ, and CK1ε. Epiblastin A inhibits the kinase activity of STK10, BRSK1, EEF2K, EGFR, MKNK2, and RIPK2. Epiblastin A inhibits Ki-67 expression, induces Oct4-GFP expression, and enhances the conversion of mouse epiblast stem cells to embryonic stem cells. Epiblastin A selectively reduces the cell viability of colorectal cancer cell lines HCT116, HT29, and DLD1. Epiblastin A can be used in colorectal cancer-related research [2] .
1
1 Cited Publications
Synonyms: DDD107498; DDD-498; M5717
Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2 .
1
1 Cited Publications
Synonyms: DDD107498 succinate; DDD-498 succinate; M5717 succinate
Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2 .
1
1 Cited Publications
Cat. No.: HY-P701676
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EEF2K; EEF-2 Kinase; Eukaryotic Elongation Factor 2 Kinase; Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor-2 Kinase; EEF-2K; Calmodulin-Dependent Protein Kinase III; CaMKIII; Eukaroytic Elongation Factor 2 Kinase; Calcium/Calmodulin-Dependent E
Species:
Human
Source:
E. coli
Target:
Research Areas:
Sordarin sodium is an eEF2 inhibitor and antibiotic. Sordarin sodium's function is dependent on the diphthamide modification on eEF2. Sordarin sodium inhibits protein synthesis by preventing the binding of eEF2 to the ribosome complex. Sordarin sodium has antifungal activity [2].
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AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way [2] .
Cat. No.: HY-RS04180
Target:
Research Areas:
EEF2 Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20725
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Research Areas:
Eef2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eef2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27237
Target:
Research Areas:
Eef2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Eef2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-112393
CAS No.: 503473-32-3
TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM) [2].
Cat. No.: HY-177720
CAS No.: 1044797-96-7
Target:
Research Areas:
eEF2K degrader-2 (Compound C1) is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer .
Cat. No.: HY-121828
CAS No.: 157397-06-3
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer [2].
Cat. No.: HY-123024
CAS No.: 51627-14-6
Synonyms: BL-S-640; SK&F 60771
Target:
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection [2].
Cat. No.: HY-P704289
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EEF2; Polypeptidyl-TRNA Translocase; Prev. EF2; Epididymis Secretory Sperm Binding Protein; Elongation Factor 2; SCA26; EEF-2; Eukaryotic Translation Elongation Factor 2; EF-2
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
