503473-32-3
Chemical Structure
TX-1918
- CAS No.: 503473-32-3
- Formula:C14H12O3
- Molecular Weight:228.24
IUPAC Name: 2-(4-hydroxy-3,5-dimethylbenzylidene)cyclopent-4-ene-1,3-dione
InChIKey: YHWRISYBKMXSGJ-UHFFFAOYSA-N
SMILES: O=C1/C(C(C=C1)=O)=C\C2=CC(C)=C(O)C(C)=C2
Biological Activity: TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM)[1][2].
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TX-1918 | TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM). | |||||||||||||||||||||
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- [1]. Hori H, et al., TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65. [Content Brief]
- [2]. Zhang DW, et al., A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. Antiviral Res. 2019 Sep;169:104544. [Content Brief]
Keywords
