278603-08-0
278603-08-0
Chemical Structure
NH125
- CAS No.: 278603-08-0
- Formula:C27H45IN2
- Molecular Weight:524.56
IUPAC Name: 3-benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide
InChIKey: RVWOHCBHAGBLLT-UHFFFAOYSA-M
SMILES: CC1=[N+](CC2=CC=CC=C2)C=CN1CCCCCCCCCCCCCCCC.[I-]
Biological Activity: NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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NH125 | 99.63% | NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes. | ||||||||||||||||||||
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References
- [1]. Arora S, et al. Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res. 2003 Oct 15;63(20):6894-9. [Content Brief]
- [2]. Kim W, et al. NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption. Future Med Chem. 2016;8(3):257-69. [Content Brief]
Keywords
