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Results for "

ERF

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

6

Recombinant Proteins

11

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150090
    SRI-41315
    1 Publications Verification

    		 CFTR Inflammation/Immunology
    SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity .
    SRI-41315
  • HY-W923189
    Neral

    		Interleukin Related COX TNF Receptor NOD-like Receptor (NLR) NO Synthase PERK p38 MAPK Reactive Oxygen Species (ROS) Caspase Autophagy Herbicide Inflammation/Immunology Cancer
    Neral is a plant-derived anti-inflammatory, antioxidant and anticancer agent. Neral inhibits the phosphorylation of ERK1/2, p38 MAPK and IκB in macrophages induced by LPS (HY-D1056), suppresses the secretion of TNF-α and IL-6, as well as the expression of pro-IL-1β, iNOS and COX-2 in cells, and reduces the production of ROS in cells. Neral inhibits the activation of the NLRP3 inflammasome, and decreases the activation of caspase-1 and the secretion of IL-1β in mouse macrophages. Neral induces autophagy, and exhibits antiproliferative activity both in in vitro breast cancer cell models and mouse xenograft models. Neral regulates brassinosteroid, jasmonic acid and ethylene signaling pathways, and induces the expression of AP2/ERF-ERF and bHLH family genes in rice roots. Neral acts as a herbicide safener, alleviates the damage induced by Fenoxaprop-P-ethyl (HY-B2013), and promotes the elongation of rice roots. Neral can be used in research related to breast cancer, inflammatory and immune system diseases, and herbicide safeners .
    Neral
  • HY-163938
    PROTAC erf3a Degrader-1

    		PROTACs Cancer
    PROTAC erf3a Degrader-1 (Compound C63) is an orally active PROTAC erf3a Degrader. PROTAC erf3a Degrader-1 inhibits cancer cell proliferation (eg: 22Rv1). PROTAC erf3a Degrader-1 can be used for research of prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer. (Red: erf3a ligand (HY-13778); Black: linker (HY-163960); Blue: CRBN ligand (HY-41547)) .
    PROTAC erf3a Degrader-1
  • HY-177569
    NVS1.1

    		Eukaryotic Initiation Factor (eIF) Others
    NVS1.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS1.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS1.1 can be used for the research of genetic diseases caused by nonsense mutations .
    NVS1.1
  • HY-120743
    Triplin

    		Biochemical Assay Reagents Metabolic Disease
    Triplin is a copper chelator, Triplin perturbs copper ion transport involved in the interaction of RAN1 and ATX1. Triplin suppresses the toxic effects of excess copper ions on plant root growth. Triplin increases the RNA expression of ERF1. Triplin acts through the ethylene signal transduction pathway. Triplin also is a bacterial pore-former .
    Triplin
  • HY-177757
    NVS2.1

    		Eukaryotic Initiation Factor (eIF) Others
    NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS2.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS2.1 can be used for the research of genetic diseases caused by nonsense mutations .
    NVS2.1
  • HY-163938A
    PROTAC erf3a Degrader-2

    		PROTACs Cancer
    PROTAC erf3a Degrader-2 (Compound C59) is an orally active PROTAC erf3a Degrader. PROTAC erf3a Degrader-2 inhibits protein expression of SRD5A3 and GSPT1(eRF3a). PROTAC erf3a Degrader-2 inhibits cancer cell proliferation (eg: 22Rv1). PROTAC erf3a Degrader-2 can be used for research of prostate cancer, ovarian cancer, liver cancer, cervical cancer, leukemia, breast cancer. (Red: erf3a ligand (HY-13778); Black: linker (HY-163960); Blue: E3 ligase ligand (HY-W763812)) .
    PROTAC erf3a Degrader-2
  • HY-RS04488
    ERF Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ERF Human Pre-designed siRNA Set A contains three designed siRNAs for ERF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ERF Human Pre-designed siRNA Set A
    ERF Human Pre-designed siRNA Set A
  • HY-153177
    PAT-IN-2

    		Ras Cancer
    PAT-IN-2 is a protein acyl transferases (PAT) inhibitor. PAT-IN-2 competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 25) .
    PAT-IN-2
  • HY-153176
    PAT-IN-1

    		Ras Cancer
    PAT-IN-1 is a protein acyl transferases (PAT) inhibitor. PAT-IN-1 competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) .
    PAT-IN-1
  • HY-RS04554
    ETF1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ETF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ETF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ETF1 Human Pre-designed siRNA Set A
    ETF1 Human Pre-designed siRNA Set A
  • HY-163960
    NH2-Ph-NH-cyclohexane-NH-Boc

    		PROTAC Linkers Cancer
    NH2-Ph-NH-cyclohexane-NH-Boc is a PROTAC linker. NH2-Ph-NH-cyclohexane-NH-Boc can be used in synthesis PROTAC erf3a Degrader-1 (HY-163938) .
    NH2-Ph-NH-cyclohexane-NH-Boc
  • HY-163961A
    Thalidomide-NH-cyclohexane-NH-Ph-NH2

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-NH-cyclohexane-NH-Ph-NH2 is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-NH-cyclohexane-NH-Ph-NH2 can be used to synthesize PROTAC erf3a Degrader-2 (HY-163938A) .
    Thalidomide-NH-cyclohexane-NH-Ph-NH2
  • HY-RS16710
    Erf Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Erf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Erf Mouse Pre-designed siRNA Set A
    Erf Mouse Pre-designed siRNA Set A
  • HY-RS23145
    Erf Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Erf Rat Pre-designed siRNA Set A contains three designed siRNAs for Erf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Erf Rat Pre-designed siRNA Set A
    Erf Rat Pre-designed siRNA Set A
  • HY-RS20729
    Etf1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Etf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Etf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Etf1 Mouse Pre-designed siRNA Set A
    Etf1 Mouse Pre-designed siRNA Set A

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