Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
Electron microscopy
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "Electron microscopy" in MCE Product Catalog:
16
16 Publications Verification
Synonyms: Ammoniated ruthenium oxychloride
3
3 Cited Publications
Cat. No.: HY-DY3001
1
1 Cited Publications
Cat. No.: HY-D1668
Cat. No.: HY-DY3002
Target:
Research Areas:
Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .
Cat. No.: HY-P11102
CAS No.: 1065010-73-2
Cat. No.: HY-W129441
CAS No.: 91281-32-2
Synonyms: N-Ac-4-S-CAP
Research Areas:
N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.
Cat. No.: HY-169197
CAS No.: 2276762-07-1
Target:
Research Areas:
D-688 is an inhibitor of Tau and Aβ. D-688 can reverse Aβ1–42-induced toxicity in SH-SH5Y cells and has significant neuroprotective properties. D-688 can improve the survival rate of Drosophila melanogaster expressing the human tau protein isoform (2N4R) .
Cat. No.: HY-111137
CAS No.: 916890-10-3
Synonyms: XC-302 free base
Puquitinib (XC-302 free base) is a multi-target inhibitor with the activity of inducing autophagy in nasopharyngeal carcinoma cells by inhibiting the PI3K/AKT/mTOR signaling pathway. Puquitinib was able to inhibit the proliferation of CNE-2 cells, showing a dose-dependent antiproliferative effect. Puquitinib induced the formation of autophagosomes and autolysosomes in CNE-2 cells, which were observed by fluorescence microscopy and electron microscopy. Puquitinib promoted the formation of LC3-II and increased the expression of beclin 1, while reducing the level of p62. Puquitinib inhibited the PI3K/AKT/mTOR pathway by reducing the expression of p-AKT and p-mTOR. Puquitinib also induced apoptosis in CNE-2 cells, and when autophagy was inhibited, the apoptosis rate was reduced, which means that autophagy may interact with apoptosis to induce cell death .
Cat. No.: HY-173283
Antifungal agent 129 (Compound 4g) is an inhibitor targeting Rhizoctonia solani, with an EC50 value of 4.27 mg/L. It has a good control effect against rice sheath blight in in vitro and in vivo experiments. Preliminary exploration through scanning electron microscopy, molecular docking, enzyme activity determination, and cytotoxicity experiments has revealed that Antifungal agent 129 may exert its inhibitory activity by affecting the cell structure or physiological processes of Rhizoctonia solani. Antifungal agent 129 can be used in the research of plant diseases in the agricultural field, such as rice sheath blight, which are caused by Rhizoctonia solani .
Cat. No.: HY-W250179
CAS No.: 5168-91-2
Synonyms: Polyoxyethylene (6) cetyl ether
Target:
Research Areas:
Aβ42 agonist-1 is a compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .
Cat. No.: HY-19227
CAS No.: 153655-35-7
Target:
Research Areas:
BM 170249 is a peroxisome proliferator, particularly in the perivenous region of the central acini in the liver. BM 170249 significantly reduces serum triglyceride and cholesterol levels in rats. BM 170249 strongly induces the activity of key enzymes in the peroxisome fatty acid β-oxidation system (such as acyl-CoA oxidase AOX, multifunctional enzyme PH, and thiolase PT), but leads to decreased activity of catalase and uricase in peroxisome components. BM 170249 could be used in lipid-lowering studies .
Cat. No.: HY-182341
CAS No.: 1261156-82-4
Target:
Research Areas:
APD-209 is a sialic acid conjugate with a PEG4 polar linker and a PDA non-polar tail. APD-209 aggregates adenovirus type 37 particles, blocks the binding of viral particles to human corneal epithelial cells, and inhibits cellular entry of adenovirus type 37. APD-209 can be used for the research of epidemic keratoconjunctivitis .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
