Aβ42 agonist-1
Based on 1 Customer Validation
Aβ42 agonist-1 is a compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 50635-12-6
- Formula: C15H11NO2
- Molecular Weight:237.25
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Aβ42 aggregation[1]
In the in vitro aggregation kinetic assays, Aβ42 agonist-1 (compound 7a) is able to demonstrate rapid increases in Aβ42 fibrillogenesis ranging from 1.5- to 4.7-fold when tested at 1, 5, 10, and 25 μM compared to Aβ42-alone control[1].
Aβ42 agonist-1 is not toxic to HT22 hippocampal neuronal cells and strikingly is able to prevent Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells (cell viability ∼74%) compared to the Aβ42-treated group (cell viability ∼20%)[1].
Aβ42 agonist-1 is able to alter the self-assembly and misfolding pathways of Aβ42 by promoting the formation of nontoxic aggregates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 50635-12-6
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Appearance Solid
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Molecular Weight 237.25
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Formula C15H11NO2
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Color Off-white to light brown
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SMILES
O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (526.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2150 mL | 21.0748 mL | 42.1496 mL | 105.3741 mL |
| 5 mM | 0.8430 mL | 4.2150 mL | 8.4299 mL | 21.0748 mL | |
| 10 mM | 0.4215 mL | 2.1075 mL | 4.2150 mL | 10.5374 mL | |
| 15 mM | 0.2810 mL | 1.4050 mL | 2.8100 mL | 7.0249 mL | |
| 20 mM | 0.2107 mL | 1.0537 mL | 2.1075 mL | 5.2687 mL | |
| 25 mM | 0.1686 mL | 0.8430 mL | 1.6860 mL | 4.2150 mL | |
| 30 mM | 0.1405 mL | 0.7025 mL | 1.4050 mL | 3.5125 mL | |
| 40 mM | 0.1054 mL | 0.5269 mL | 1.0537 mL | 2.6344 mL | |
| 50 mM | 0.0843 mL | 0.4215 mL | 0.8430 mL | 2.1075 mL | |
| 60 mM | 0.0702 mL | 0.3512 mL | 0.7025 mL | 1.7562 mL | |
| 80 mM | 0.0527 mL | 0.2634 mL | 0.5269 mL | 1.3172 mL | |
| 100 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0537 mL |
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