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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
FAK-IN-4
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "FAK-IN-4" in MCE Product Catalog:
BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 is a FAK (HY-43760) ligand and linker conjugate. BI-4464 can be used to construct proteolysis targeting chimeras (PROTACs), such as PROTAC FAK degrader 4 (HY-178467). PROTAC FAK degrader 4 is a highly potent and selective FAK PROTAC degrader .
Cat. No.: HY-178467
PROTAC FAK degrader 4 is a potent FAK PROTAC degrader with a DC50 of 3.6 nM. PROTAC FAK degrader 4 induces FAK ubiquitination and degradation via the VHL-dependent ubiquitin-proteasome pathway. PROTAC FAK degrader 4 inhibits cell proliferation, colony formation, migration and invasion. Combination of PROTAC FAK degrader 4 with Cisplatin (HY-17394) enhances chemosensitivity. PROTAC FAK degrader 4 can be used in research related to breast cancer .
Cat. No.: HY-43760
CAS No.: 1227948-58-4
Research Areas:
FAK ligand-5 is a FAK ligand. FAK ligand-5 can be coupled with a linker to synthesize BI-4464 (HY-124625). FAK ligand-5 can be used as a target protein ligand for PROTAC development, specifically for designing PROTAC FAK degraders. FAK ligand-5 can be used in the synthesis of PROTAC FAK degrader 4 (HY-178467). FAK ligand-5 can be used in cancer research .
Cat. No.: HY-W208616
CAS No.: 2952-00-3
Target:
Research Areas:
trans-4-Aminocyclohexylacetic acid is a PROTAC linker that can be used in the synthesis of PROTACs, such as PROTAC FAK degrader 4 (HY-178467) .
Cat. No.: HY-178483
Research Areas:
E3 Ligase Ligand-linker Conjugate 211 is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. E3 Ligase Ligand-linker Conjugate 211 can be used to synthesize PROTAC FAK degrader 4 (HY-178467) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
