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Results for "

Fluorescent tag

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fluorescent Dye (44) Amyloid-β (1) Apoptosis (1) Biochemical Assay Reagents (5) COX (1) Dipeptidyl Peptidase (1) DNA Stain (3) Drug Intermediate (1) Drug Metabolite (2) Endothelin Receptor (1) iGluR (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Liposome (1) MMP (1) NF-κB (1) Phospholipase (1) Phosphoramidites (1) Prostaglandin Receptor (1) TNF Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (3)
Click Chemistry:	Labeling and Fluorescence Imaging (2) Azide (4) Alkynes (2)
Oligonucleotides:	Fluorescent Dye Phosphoramidite (1) Phosphoramidites (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Fluorescent Dye

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0021

EthD bromide 25+ Cited Publications EtBr; Homidium bromide	DNA Stain	Others
EthD bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis.

HY-D2270

Halo tag TMR 2 Publications Verification	Fluorescent Dye	Others
Halo tag TMR is a red fluorescent dye composed of Halo tag ligand molecules and TMR (TAMRA). Halo tag can quickly and stably covalently bind to Halo protein with high specificity and affinity (Ex/Em = 550/576 nm) .

HY-164745

L-β-Ethynylserine	Fluorescent Dye	Others
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags, respectively .

HY-D1314

FAM azide, 6-isomer 6-FAM azide	Fluorescent Dye	Others
FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

HY-W017776

BG-NH2 SNAP-NH2	Drug Intermediate	Others
BG-NH2 is a pharmaceutical intermediate. BG-NH2 is suitable for synthesizing fluorescent SNAP tag substrates to label RNA .

HY-DY1050

Ethidium bromide (solution)	DNA Stain	Others
Ethidium bromide (solution) is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. Solvent and Concentration: Sterile water: 10 mg/Ml

HY-D1506

Fl-DIBO	Fluorescent Dye	Others
Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126192

Pittsburgh Compound B PiB; 6-OH-BTA-1	Amyloid-β	Neurological Disease
Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Aβ deposition PET tracer that binds to Aβ(1-40) fibrils with a K_i value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Aβ complexes. Pittsburgh Compound B is applicable to Alzheimer's disease research .

HY-W039953

Ac4GlcNAz N-azidoacetylglucosamine-tetraacylated	Biochemical Assay Reagents	Others
Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions.

HY-131028

*Janelia Fluor® 646 TFA* JF646 TFA	Fluorescent Dye	Others
Janelia Fluor 646 TFA (JF646 TFA), a red fluorogenic fluorescent dye, can be used in the synthesis of Janelia Fluor 646 HaloTag and SNAP-Tag ligands. JF646 TFA is used in live cell imaging experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-130736

*Janelia Fluor® 549, SE* JF549, SE; JF549, NHS	Fluorescent Dye	Others
Janelia Fluor® 549, SE (JF549, SE) is a cell-permeable fluorescent dye with an NHS ester (succinimidyl ester (SE)) reactive group. NHS esters react with primary amines and are commonly used to conjugate dyes to proteins, antibodies, amine-modified oligonucleotides, and other molecules. Janelia Fluor® 549, SE also acts as a ligand for self-labeling tags such as HaloTag and SNAP-tag, and can be used in live-cell imaging studies (Ex/Em = 549 nm/571 nm) .\n

HY-D1584

C12 NBD Sphingomyelin	Phospholipase	Others
C12 NBD sphingomyelin is an active derivative of Sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm) .

HY-D1690A

sBADA	Fluorescent Dye	Others
sBADA is a potent green fluorescent dye. sBADA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-W778830

Bodipy C12-ceramide	Drug Metabolite	Neurological Disease
Bodipy C12-ceramide (B12Cer) is a fluorescently tagged form of C12-Ceramide (HY-100353) that displays excitation/emission maxima of 505/540 nm, respectively. Bodipy C12-ceramide is formed when acid sphingomyelinase hydrolyzes BODIPY-C12 sphingomyelin in vitro and has been used to quantify acid sphingomyelinase activity in plasma with Niemann-Pick disease .

HY-148947

Cy5 Phosphoramidite	Fluorescent Dye Phosphoramidites	Others
Cy5 Phosphoramidite is a fluorescent labeling reagent . Cy5 Phosphoramidite serves as a fluorescent tag for 3' terminal labeling of single-stranded DNA, enabling fluorescence-based nucleic acid detection, monitoring, quantification, and in vitro study .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-D2965

SNAP-Peroxy-Green-1 SPG1	Fluorescent Dye	Others
SNAP-Peroxy-Green-1 (SPG1) a SNAP tag fluorescent probe. SNAP-Peroxy-Green-1 can be used for detecting H₂O₂ in the extracellular space or on the surface of the cell membrane .

HY-W039924

N-Azidoacetylmannosamine 1 Publications Verification	Drug Metabolite	Metabolic Disease
N-Azidoacetylmannosamine is an azide-labeled sugar that can be metabolically incorporated into glycoproteins. N-Azidoacetylmannosamine can then react with alkynes or phosphines that are linked to fluorescent or biotin tags for visualization or capture of the glycoproteins. N-Azidoacetylmannosamine can be used for studying glycan structures and functions in vivo .

HY-D1575

C6 NBD Galactosylceramide	Fluorescent Dye	Others
C6 NBD galactosylceramide is an active derivative of galactosylceramide that is tagged with fluorescent C6 nitrobenzoxadiazole (C6 NBD). C6 NBD galactosylceramide can be used as a substrate for neutral β-glycosylceramidase (GCase) to study intracellular localization and metabolism of galactosylceramide (Ex=nm, Em=525) .

HY-W800701

*BP Fluor* 546 DBCO**	Biochemical Assay Reagents	Others
BP Fluor 546 DBCO is an azide-reactive probe that can be used for imaging azide-tagged biomolecules via a copper-free click reaction. The DBCO moiety reacts with azides to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 546 DBCO is an ideal alternative to copper-requiring fluorescent alkynes. BP Fluor 546 is a water-soluble, pH-insensitive (from pH 4-10), orange-fluorescent dye with absorption and emission maxima at 554 and 570 nm, respectively. It can be used with the 488 nm and 532 nm laser lines. BP Fluor 546 dye conjugates to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, which are often used for generating stable signals in imaging and flow cytometry.

HY-P11263

AVLX-144	iGluR	Neurological Disease
AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95). AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease .

HY-148958

SNAP-Biotin	Biochemical Assay Reagents	Others
SNAP-Biotin is a biotin-labeled SNAP tag probe. SNAP-Biotin can be used for protein biotinylation .

HY-D2944

SNAP-649	Fluorescent Dye	Others
SNAP-649 is a DY-649P1-labeled SNAP tag fluorescent probe.

HY-D2931

SNAP-FAM	Fluorescent Dye	Others
SNAP-FAM is a FAM-labeled SNAP tag fluorescent probe, specifically designed for live-cell protein labeling and real-time imaging applications .

HY-D2949

SNAP-549	Fluorescent Dye	Others
SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation .

HY-D2933

SNAP-505	Fluorescent Dye	Others
SNAP-505 is a green fluorescent O6 benzylguanine derivative. SNAP-505 labels SNAP-tagged proteins covalently. SNAP-505 can be used to label cells (green) .

HY-D2952

BOCA-1-BG	Fluorescent Dye	Others
BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe. BOCA-1-BG can be used to detect Ca ²⁺ concentration and serves as a highly sensitive Ca ²⁺ fluorescent indicator .

HY-113217F

BODIPY 480/508-cholesteryl oleate	Fluorescent Dye Liposome	Metabolic Disease
BODIPY 480/508-cholesteryl oleate is a fluorescently tagged derivative of Cholesteryl oleate (HY-113217). BODIPY 480/508-cholesteryl oleate can be used to monitor lipid transport mechanisms in mammalian cells (Ex/Em = 480/508 nm) .

HY-D2940

SiR-SNAP SiR650-BG	Fluorescent Dye	Others
SiR-SNAP (SiR650-BG) is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells .

HY-D2960

BC-OG CLIP-OG	Fluorescent Dye	Others
BC-OG is an oregon green labeled CLIP tag fluorescent probe. BC-OG can be used for labeling CLIP-tag fusion protein in cells .

HY-D2961

SiR-CLIP	Fluorescent Dye	Others
SiR-CLIP is a SiR-carboxyl derivative used for covalent fluorescent labeling of CLIP tags .

HY-D2948

SNAP-430	Fluorescent Dye	Others
SNAP-430 is a (diethylamino) coumarin-labeled SNAP tag fluorescent probe. SNAP-430 can be used for making SNAP-tag fusion proteins inside living cells, on cell surfaces, or in vitro.

HY-D2946

CLIP-TMR BC-TMR	Fluorescent Dye	Infection
CLIP-TMR (BC-TMR) is a TMR-labeled CLIP tag fluorescent probe. CLIP-TMR combines the high specificity recognition ability of the CLIP-tag and the excellent optical performance of the TMR fluorophore, and can be used for the specific labeling and visualization of the HCV NS5A protein .

HY-145493

C12 NBD Galactosylceramide	Fluorescent Dye	Others
C12 NBD galactosylceramide, fluorescent dye, is a biologically active derivative of galactosylceramide that is tagged with a fluorescent C12 nitrobenzoxadiazole (C12 NBD) group. C12 NBD galactosylceramide can be used for the research of imaging .

HY-D0021S

EthD-d5 bromide EtBr-d5; Homidium-d5 bromide	Isotope-Labeled Compounds DNA Stain	Others
EthD-d₅ bromide is the deuterium labeled Ethidium bromide. EthD bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis.

HY-D1579

C12 NBD Globotriaosylceramide	Fluorescent Dye	Others
C12 NBD galactosylceramide is a biologically active derivative of galactosylceramide that is tagged with a fluorescent C12 nitrobenzoxadiazole (C12 NBD) group. C12 NBD galactosylceramide has been used to detect ceramide trihexoside .

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dye	Others
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

HY-D2943

BG-SS-SulfoCy3 SNAP-SS-SulfoCy3	Fluorescent Dye	Others
BG-SS-SulfoCy3 is a SulfoCy3-labeled SNAP tag fluorescent probe, which is linked by a disulfide bond to achieve selective labeling and controllable cleavage. BG-SS-SulfoCy3 can be used to study the endocytosis and trafficking of membrane proteins such as GPCRs .

HY-D2480

BODIPY 480/508-cholesteryl linoleate	Fluorescent Dye	Metabolic Disease
BODIPY 480/508-cholesteryl linoleate is a cell-permeable and fluorescently tagged derivative of Cholesteryl Linoleate (HY-W010697). BODIPY 480/508-cholesteryl linoleate has been used to monitor cholesterol trafficking in isolated human monocyte-derived macrophages (Ex/Em=480/508 nm).

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Biochemical Assay Reagents	Cancer
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

HY-D1690

sBADA TFA	Fluorescent Dye	Others
sBADA TFA is a potent green fluorescent dye. sBADA TFA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA TFA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-D2964

NBzF-BG	Fluorescent Dye	Others
NBzF-BG is a novel H₂O₂-specific fluorescent probe. NBzF-BG shows visible absorption centered at 505 nm and weak fluorescence with an emission maximum at 525 nm. NBzF-BG is covalently and selectively conjugated with the SNAP-tag protein, leading to formation of the fluorophore-protein conjugate (SNAP-NBzF). SNAP-NBzF rapidly reacts with H₂O₂ and thereby shows an enhancement in fluorescence .

HY-138658

*Janelia Fluor® 526, SE* JF526, SE; JF526, NHS	Fluorescent Dye	Others
Janelia Fluor 526, SE (JF526,SE) is a fluorogenic yellow fluorescent dye that contains NHS ester group. JF526 is a versatile scaffold for fluorogenic ligands, including labels for genetically encoded self-labeling protein tags and stains for endogenous structures . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-W800696

*BP Fluor* 430 azide**	Fluorescent Dye	Others
BP Fluor 430 Azide is a water-soluble, green-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. BP Fluor 430 is a bright, photostable, green-fluorescent probe with excitation near its absorption maximum at 432 nm and emission maximum at 539 nm. This probe is water soluble and pH-insensitive from pH 4 to pH 10. A next generation probe, BP Fluor 430 Picolyl Azide, is also available for detection of low abundance alkyne-tagged biomolecules.

HY-D2327

DPP-8/9 probe-1	Dipeptidyl Peptidase	Others
DPP-8/9 probe-1 (compound 20) is a fluorescent probe targeting Dipeptidyl Peptidase DPP8/9, which can be selectively labeled and visualized in vitro by fluorescence microscopy Active DPP8/9. DPP-8/9 probe-1 contains a nitrobenzoxadiazole (NBD) tag and has high affinity and selectivity for DPP8/9 over related S9 family members (IC₅₀ of 210 nM and 15 nM, respectively) .

HY-W800838

*BP Fluor* 488 Tetrazine**	Fluorescent Dye	Cancer
BP Fluor 488 Tetrazine is a bright, green-fluorescent probe used for detection TCO-tagged biopolymers. BP Fluor 488 Tetrazine demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In applications such as in vivo cancer imaging or pre?targeted cell labeling studies where rapid reaction kinetics is a must BP Fluor 488 Tetrazine probe would of great value.

HY-D1597

Cyanine3.5 azide chloride	Fluorescent Dye	Others
Cyanine3.5 azide chloride, an analog of Cyanine3.5 azide, is a potent green fluorescent dye. Cyanine3.5 azide chloride uses click chemistry to tag the ethylidene group. (λ_ex=591 nm, λ_em=604 nm) . Cyanine3.5 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-D2941

BGAF SNAP-AF	Fluorescent Dye	Others
BGAF (SNAP-AF) is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .

HY-D2945

CLIP-Biotin	Fluorescent Dye	Others
CLIP-Biotin is a Biotin-labeled CLIP tag fluorescent probe. CLIP-Biotin can be used for marking the CLIP-tag fusion proteins in cells.

HY-D2959

BC-DF CLIP-DF	Fluorescent Dye	Others
BC-DF is a diacetyl fluorescein labeled CLIP tag fluorescent probe. BC-DF can be used for labeling CLIP-tag fusion protein in cells .

Cat. No.	Product Name	Type

HY-D0021

EthD bromide 25+ Cited Publications EtBr; Homidium bromide	Fluorescent Dyes
EthD bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis.

HY-D2270

Halo tag TMR 2 Publications Verification	Fluorescent Dyes
Halo tag TMR is a red fluorescent dye composed of Halo tag ligand molecules and TMR (TAMRA). Halo tag can quickly and stably covalently bind to Halo protein with high specificity and affinity (Ex/Em = 550/576 nm) .

HY-D1314

FAM azide, 6-isomer

6-FAM azide

Fluorescent Dyes

FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

HY-W017776

BG-NH2 SNAP-NH2	Fluorescent Dyes
BG-NH2 is a pharmaceutical intermediate. BG-NH2 is suitable for synthesizing fluorescent SNAP tag substrates to label RNA .

HY-DY1050

Ethidium bromide (solution)	Fluorescent Dyes
Ethidium bromide (solution) is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. Solvent and Concentration: Sterile water: 10 mg/Ml

HY-D1506

Fl-DIBO

Fluorescent Dyes

Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131028

*Janelia Fluor® 646 TFA* JF646 TFA	Fluorescent Dyes
Janelia Fluor 646 TFA (JF646 TFA), a red fluorogenic fluorescent dye, can be used in the synthesis of Janelia Fluor 646 HaloTag and SNAP-Tag ligands. JF646 TFA is used in live cell imaging experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-130736

Janelia Fluor® 549, SE

JF549, SE; JF549, NHS

Fluorescent Dyes

Janelia Fluor® 549, SE (JF549, SE) is a cell-permeable fluorescent dye with an NHS ester (succinimidyl ester (SE)) reactive group. NHS esters react with primary amines and are commonly used to conjugate dyes to proteins, antibodies, amine-modified oligonucleotides, and other molecules. Janelia Fluor® 549, SE also acts as a ligand for self-labeling tags such as HaloTag and SNAP-tag, and can be used in live-cell imaging studies (Ex/Em = 549 nm/571 nm) .\n

HY-D1584

C12 NBD Sphingomyelin	Fluorescent Dyes
C12 NBD sphingomyelin is an active derivative of Sphingomyelin (HY-113498) that is tagged with fluorescent C12 nitrobenzoxadiazole (C12 NBD). C12 NBD sphingomyelin can be used as a sphingomyelinase substrate for studying the metabolism and transport of sphingomyelins (Ex=470 nm, Em=525 nm) .

HY-D2965

SNAP-Peroxy-Green-1 SPG1	Fluorescent Dyes
SNAP-Peroxy-Green-1 (SPG1) a SNAP tag fluorescent probe. SNAP-Peroxy-Green-1 can be used for detecting H₂O₂ in the extracellular space or on the surface of the cell membrane .

HY-D1575

C6 NBD Galactosylceramide	Fluorescent Dyes
C6 NBD galactosylceramide is an active derivative of galactosylceramide that is tagged with fluorescent C6 nitrobenzoxadiazole (C6 NBD). C6 NBD galactosylceramide can be used as a substrate for neutral β-glycosylceramidase (GCase) to study intracellular localization and metabolism of galactosylceramide (Ex=nm, Em=525) .

HY-W800701

BP Fluor 546 DBCO

Fluorescent Dyes

BP Fluor 546 DBCO is an azide-reactive probe that can be used for imaging azide-tagged biomolecules via a copper-free click reaction. The DBCO moiety reacts with azides to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 546 DBCO is an ideal alternative to copper-requiring fluorescent alkynes. BP Fluor 546 is a water-soluble, pH-insensitive (from pH 4-10), orange-fluorescent dye with absorption and emission maxima at 554 and 570 nm, respectively. It can be used with the 488 nm and 532 nm laser lines. BP Fluor 546 dye conjugates to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, which are often used for generating stable signals in imaging and flow cytometry.

HY-148958

SNAP-Biotin	Fluorescent Dyes
SNAP-Biotin is a biotin-labeled SNAP tag probe. SNAP-Biotin can be used for protein biotinylation .

HY-D2944

SNAP-649	Fluorescent Dyes
SNAP-649 is a DY-649P1-labeled SNAP tag fluorescent probe.

HY-D2931

SNAP-FAM	Fluorescent Dyes
SNAP-FAM is a FAM-labeled SNAP tag fluorescent probe, specifically designed for live-cell protein labeling and real-time imaging applications .

HY-D2949

SNAP-549	Fluorescent Dyes
SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation .

HY-D2933

SNAP-505	Fluorescent Dyes
SNAP-505 is a green fluorescent O6 benzylguanine derivative. SNAP-505 labels SNAP-tagged proteins covalently. SNAP-505 can be used to label cells (green) .

HY-D2952

BOCA-1-BG	Fluorescent Dyes
BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe. BOCA-1-BG can be used to detect Ca ²⁺ concentration and serves as a highly sensitive Ca ²⁺ fluorescent indicator .

HY-113217F

BODIPY 480/508-cholesteryl oleate	Fluorescent Dyes
BODIPY 480/508-cholesteryl oleate is a fluorescently tagged derivative of Cholesteryl oleate (HY-113217). BODIPY 480/508-cholesteryl oleate can be used to monitor lipid transport mechanisms in mammalian cells (Ex/Em = 480/508 nm) .

HY-D2940

SiR-SNAP SiR650-BG	Fluorescent Dyes
SiR-SNAP (SiR650-BG) is a SiR-labeled SNAP tag near-infrared fluorescent probe (Ex/Em: 645 nm/661 nm). SiR-SNAP combines excellent optical properties, good cell membrane permeability, and environmentally sensitive fluorescence characteristics, providing a powerful tool for the dynamic study of proteins in living cells .

HY-D2960

BC-OG CLIP-OG	Fluorescent Dyes
BC-OG is an oregon green labeled CLIP tag fluorescent probe. BC-OG can be used for labeling CLIP-tag fusion protein in cells .

HY-D2961

SiR-CLIP	Fluorescent Dyes
SiR-CLIP is a SiR-carboxyl derivative used for covalent fluorescent labeling of CLIP tags .

HY-D2948

SNAP-430	Fluorescent Dyes
SNAP-430 is a (diethylamino) coumarin-labeled SNAP tag fluorescent probe. SNAP-430 can be used for making SNAP-tag fusion proteins inside living cells, on cell surfaces, or in vitro.

HY-D2946

CLIP-TMR BC-TMR	Fluorescent Dyes
CLIP-TMR (BC-TMR) is a TMR-labeled CLIP tag fluorescent probe. CLIP-TMR combines the high specificity recognition ability of the CLIP-tag and the excellent optical performance of the TMR fluorophore, and can be used for the specific labeling and visualization of the HCV NS5A protein .

HY-145493

C12 NBD Galactosylceramide	Fluorescent Dyes
C12 NBD galactosylceramide, fluorescent dye, is a biologically active derivative of galactosylceramide that is tagged with a fluorescent C12 nitrobenzoxadiazole (C12 NBD) group. C12 NBD galactosylceramide can be used for the research of imaging .

HY-D1579

C12 NBD Globotriaosylceramide	Fluorescent Dyes
C12 NBD galactosylceramide is a biologically active derivative of galactosylceramide that is tagged with a fluorescent C12 nitrobenzoxadiazole (C12 NBD) group. C12 NBD galactosylceramide has been used to detect ceramide trihexoside .

HY-D1749

C6 NBD L-threo-ceramide	Fluorescent Dyes
C6 NBD L-threo-ceramide is a cell-permeable analog of ceramides that is tagged with a fluorescent group C6 nitrobenzoxadiazole (C6 NBD). It is rapidly transferred between liposomes, labels the Golgi apparatus, and is metabolized to C6 NBD sphingomyelin in BHK cells and V79 fibroblasts.

HY-D2943

BG-SS-SulfoCy3 SNAP-SS-SulfoCy3	Fluorescent Dyes
BG-SS-SulfoCy3 is a SulfoCy3-labeled SNAP tag fluorescent probe, which is linked by a disulfide bond to achieve selective labeling and controllable cleavage. BG-SS-SulfoCy3 can be used to study the endocytosis and trafficking of membrane proteins such as GPCRs .

HY-D2480

BODIPY 480/508-cholesteryl linoleate	Fluorescent Dyes
BODIPY 480/508-cholesteryl linoleate is a cell-permeable and fluorescently tagged derivative of Cholesteryl Linoleate (HY-W010697). BODIPY 480/508-cholesteryl linoleate has been used to monitor cholesterol trafficking in isolated human monocyte-derived macrophages (Ex/Em=480/508 nm).

HY-D1690

sBADA TFA	Fluorescent Dyes
sBADA TFA is a potent green fluorescent dye. sBADA TFA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA TFA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-D2964

NBzF-BG

Fluorescent Dyes

NBzF-BG is a novel H₂O₂-specific fluorescent probe. NBzF-BG shows visible absorption centered at 505 nm and weak fluorescence with an emission maximum at 525 nm. NBzF-BG is covalently and selectively conjugated with the SNAP-tag protein, leading to formation of the fluorophore-protein conjugate (SNAP-NBzF). SNAP-NBzF rapidly reacts with H₂O₂ and thereby shows an enhancement in fluorescence .

HY-138658

Janelia Fluor® 526, SE

JF526, SE; JF526, NHS

Fluorescent Dyes

Janelia Fluor 526, SE (JF526,SE) is a fluorogenic yellow fluorescent dye that contains NHS ester group. JF526 is a versatile scaffold for fluorogenic ligands, including labels for genetically encoded self-labeling protein tags and stains for endogenous structures . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-W800696

BP Fluor 430 azide

Fluorescent Dyes

BP Fluor 430 Azide is a water-soluble, green-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. BP Fluor 430 is a bright, photostable, green-fluorescent probe with excitation near its absorption maximum at 432 nm and emission maximum at 539 nm. This probe is water soluble and pH-insensitive from pH 4 to pH 10. A next generation probe, BP Fluor 430 Picolyl Azide, is also available for detection of low abundance alkyne-tagged biomolecules.

HY-D2327

DPP-8/9 probe-1	Fluorescent Dyes
DPP-8/9 probe-1 (compound 20) is a fluorescent probe targeting Dipeptidyl Peptidase DPP8/9, which can be selectively labeled and visualized in vitro by fluorescence microscopy Active DPP8/9. DPP-8/9 probe-1 contains a nitrobenzoxadiazole (NBD) tag and has high affinity and selectivity for DPP8/9 over related S9 family members (IC₅₀ of 210 nM and 15 nM, respectively) .

HY-W800838

BP Fluor 488 Tetrazine

Fluorescent Dyes

BP Fluor 488 Tetrazine is a bright, green-fluorescent probe used for detection TCO-tagged biopolymers. BP Fluor 488 Tetrazine demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In applications such as in vivo cancer imaging or pre?targeted cell labeling studies where rapid reaction kinetics is a must BP Fluor 488 Tetrazine probe would of great value.

HY-D2941

BGAF SNAP-AF	Fluorescent Dyes
BGAF (SNAP-AF) is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .

HY-D2945

CLIP-Biotin	Fluorescent Dyes
CLIP-Biotin is a Biotin-labeled CLIP tag fluorescent probe. CLIP-Biotin can be used for marking the CLIP-tag fusion proteins in cells.

HY-D2959

BC-DF CLIP-DF	Fluorescent Dyes
BC-DF is a diacetyl fluorescein labeled CLIP tag fluorescent probe. BC-DF can be used for labeling CLIP-tag fusion protein in cells .

HY-DY1107

Halo tag TMR (solution)	Fluorescent Dyes
Halo tag TMR (solution) is a red fluorescent dye composed of Halo tag ligand molecules and TMR (TAMRA). Halo tag can quickly and stably covalently bind to Halo protein with high specificity and affinity (Ex/Em = 550/576 nm) . Solvent and concentration: DMSO: 5 mM

HY-D2939

BGSBD

Fluorescent Dyes

BGSBD is a SNAP-tag-based fluorescent probe (Ex/Em: 435 nm/516 nm) based on the environmentally sensitive fluorescent group SBD, specifically designed for protein labeling of live cells without washing. BGSBD achieves a 280-fold fluorescence enhancement after labeling by ingeniously utilizing the hydrophobic binding pocket of the SNAP-tag protein, providing an ideal tool for real-time monitoring of protein dynamics within cells .

HY-D2951

BG-Kaede chromophore	Fluorescent Dyes
BG-Kaede chromophore (Compound 4c) is a SNAP-tag-specific fluorescent probe, which is designed and synthesized using the chromophore of the red fluorescent protein Kaede as a template. BG-Kaede chromophore can be used as a tool for visualizing proteins in living cells .

HY-D2930

BG-SS-SulfoCy5 SNAP-SS-SulfoCy5	Fluorescent Dyes
BG-SS-SulfoCy5 (SNAP-SS-SulfoCy5) is a SulfoCy5-labeled SNAP tag fluorescent probe, linked by a disulfide bond. BG-SS-SulfoCy5 combines the specific recognition of SNAP-tag, the cleavability of disulfide bond, and the excellent optical properties of SulfoCy5. BG-SS-SulfoCy5 can be used for tracking the internalization of cell surface proteins and multiple labeling experiments .

HY-D2958

ZP1BG	Fluorescent Dyes
ZP1BG is a SNAP tag fluorescent probe for detecting Zn ²⁺, which is formed by the covalent connection of the zinc sensor ZP1 from the Zinpyr family with the benzyl guanine group. ZP1BG can be used to detect the concentration of Zn ²⁺ in neuronal organelles such as the Golgi apparatus and mitochondria .

HY-D2924

CBG-549-QSY7

Fluorescent Dyes

CBG-549-QSY7 is a Dylight 549-labeled SNAP tag fluorescent probe (Ex/Em: 546 nm/580 nm), specially designed for non-washable fluorescence imaging applications. CBG-549-QSY7 employs an intramolecular FRET quenching mechanism: intramolecular fluorescence quenching occurs before binding to the SNAP tag, and upon binding, the quenching group is cleaved, releasing fluorescence. The background fluorescence of CBG-549-QSY7 is extremely low, and clear cell membrane images can be obtained after 5 minutes of incubation .

HY-D2942

BDP-V BG-BODIPY

Fluorescent Dyes

BDP-V BG-BODIPY is a SNAP tag fluorescent probe labeled with a BODIPY molecular motor. BDP-V BG-BODIPY contains a BODIPY molecular rotor that functions as a viscosity-sensitive fluorophore, which is highly responsive to local viscosity changes and enables the specific monitoring of the local microviscosity of proteins. BDP-V BG-BODIPY supports one-photon and two-photon imaging, with an excitation wavelength (Ex) of 488 nm (for one-photon excitation) and 850 nm (for two-photon excitation), and an emission wavelength (Em) of 500-600 nm .

Cat. No.	Product Name	Target	Research Area

HY-P0327

T7 Tag Peptide 1 Publications Verification	Peptides	Others
T7 Tag Peptide is a protein tag peptide composed of 11 residues from the N-terminus of gp10, the capsid protein of T7 bacteriophage. T7 Tag Peptide can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide is applicable for various immunoassays and affinity purification .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P11263

AVLX-144	iGluR	Neurological Disease
AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95). AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease .

HY-P0327A

T7 Tag Peptide TFA 1 Publications Verification	Peptides	Others
T7 Tag Peptide TFA is a protein tag consisting of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. T7 Tag Peptide TFA can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide TFA can be used in various immunoassays and affinity purification .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Species independent (3)
Application:	IHC-P (2) ICC/IF (2) IF-Tissue (2) IHC-F (2) WB (3) FC (2) ELISA (2)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86717

	RFP Tag Antibody (YA6409) Red Fluorescent protein; Red Fluorescent protein eqFP611; RFPtag; RFP-tag; RFP tag; RFP_ENTQU.	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA, IF-Tissue	Species independent
	RFP Tag Antibody (YA6409) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to RFP.

HY-P86717A

	RFP Tag Antibody (YA6409)(PBS only) Red Fluorescent protein; Red Fluorescent protein eqFP611; RFPtag; RFP-tag; RFP tag; RFP_ENTQU.	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA, IF-Tissue	Species independent
	RFP Tag Antibody (YA6409) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to RFP.

HY-P87050

	RFP Tag Antibody (YA6743) DsRed antibody; GFP like chromoprotein antibody; red Fluorescent protein antibody; RFP antibody;	WB	Species independent
	RFP Tag Antibody (YA6743) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RFP.

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Cat. No.	Product Name		Classification

HY-164745

L-β-Ethynylserine		Alkynes
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags, respectively .

HY-D1314

FAM azide, 6-isomer 6-FAM azide		Azide Labeling and Fluorescence Imaging
FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

HY-D1506

Fl-DIBO		Labeling and Fluorescence Imaging
Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W039953

Ac4GlcNAz N-azidoacetylglucosamine-tetraacylated		Azide
Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions.

HY-W039924

N-Azidoacetylmannosamine 1 Publications Verification		Azide
N-Azidoacetylmannosamine is an azide-labeled sugar that can be metabolically incorporated into glycoproteins. N-Azidoacetylmannosamine can then react with alkynes or phosphines that are linked to fluorescent or biotin tags for visualization or capture of the glycoproteins. N-Azidoacetylmannosamine can be used for studying glycan structures and functions in vivo .

HY-D1597

Cyanine3.5 azide chloride		Azide
Cyanine3.5 azide chloride, an analog of Cyanine3.5 azide, is a potent green fluorescent dye. Cyanine3.5 azide chloride uses click chemistry to tag the ethylidene group. (λ_ex=591 nm, λ_em=604 nm) . Cyanine3.5 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-176102

C6 Ceramide (d18:1/6:0) alkyne N-Hexanoyl-D-erythro-sphingosine alkyne		Alkynes
C6 Ceramide (d18:1/6:0) alkyne is an ω-alkyne derivative of C6 ceramide. The terminal alkyne group can be used in click chemistry reactions to tag C6 ceramide with fluorescent or biotinylated labels, allowing the analysis of the metabolism and biological activity of C6 ceramide.

Cat. No.	Product Name		Classification

HY-148947

Cy5 Phosphoramidite		Phosphoramidites Fluorescent Dye Phosphoramidite
Cy5 Phosphoramidite is a fluorescent labeling reagent . Cy5 Phosphoramidite serves as a fluorescent tag for 3' terminal labeling of single-stranded DNA, enabling fluorescence-based nucleic acid detection, monitoring, quantification, and in vitro study .

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