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GADD153

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By Targets:	Akt (1) AMPK (1) Apoptosis (1) Autophagy (1) Bacterial (1) Caspase (1) EGFR (1) FABP (1) FAK (1) GLUT (1) HIV (1) HSP (1) IAP (1) JNK (1) MDM-2/p53 (1) mTOR (1) PARP (1) PERK (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (3) SOD (1) VEGFR (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119500

Ilimaquinone 2 Publications Verification	HIV Bacterial	Infection Inflammation/Immunology Cancer
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-N2445

Flavokawain C 4 Publications Verification	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK	Cancer
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates *GADD153* in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

HY-RS24534

Ddit3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddit3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddit3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddit3 Rat Pre-designed siRNA Set A Ddit3 Rat Pre-designed siRNA Set A

HY-RS18059

Ddit3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddit3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddit3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddit3 Mouse Pre-designed siRNA Set A Ddit3 Mouse Pre-designed siRNA Set A

HY-RS03614

DDIT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DDIT3 Human Pre-designed siRNA Set A contains three designed siRNAs for DDIT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DDIT3 Human Pre-designed siRNA Set A DDIT3 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119500

Ilimaquinone 2 Publications Verification	Infection Quinones Classification of Application Fields Animals Marine natural products Benzene Quinones Sponge Inflammation/Immunology Disease Research Fields Cancer	HIV Bacterial
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-N2445

Flavokawain C 4 Publications Verification	Structural Classification Classification of Application Fields Piperaceae Plants Chalcones Flavonoids other families Phenols Polyphenols Piper methysticum G.Forst. Disease Research Fields Source Classification Cancer	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates *GADD153* in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (4) ICC/IF (2) IF-Tissue (2) IHC-F (2) WB (4)
Isotype:	IgG (3) IgG1 (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81233

	DDIT3 Antibody (YA3507) 1 Publications Verification GADD153; CHOP; Growth arrest and DNA damage-inducible 153; C/EBP homologous protein; C/EBP Homology Protein; CEBPZ; CHOP10; DDIT 3; DNA Damage Inducible Transcript 3; GADD 153; Growth Arrest and DNA Damage Inducible Protein 153; Growth arrest and DNA damage inducible protein GADD153; MGC4154; DDIT3_HUMAN.	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	DDIT3 Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDIT3.

HY-P81233A

	DDIT3 Antibody (YA3507)(PBS only) GADD153; CHOP; Growth arrest and DNA damage-inducible 153; C/EBP homologous protein; C/EBP Homology Protein; CEBPZ; CHOP10; DDIT 3; DNA Damage Inducible Transcript 3; GADD 153; Growth Arrest and DNA Damage Inducible Protein 153; Growth arrest and DNA damage inducible protein GADD153; MGC4154; DDIT3_HUMAN.	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	DDIT3 Antibody is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDIT3.

HY-P89393

	DDIT3 Antibody (YA8849) GADD153; CHOP; Growth arrest and DNA damage-inducible 153; C/EBP homologous protein; C/EBP Homology Protein; CEBPZ; CHOP10; DDIT 3; DNA Damage Inducible Transcript 3; GADD 153; Growth Arrest and DNA Damage Inducible Protein 153; Growth arrest and DNA damage inducible protein GADD153; MGC4154; DDIT3_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	DDIT3 Antibody is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DDIT3.

HY-P89394

	DDIT3 Antibody (YA8849)(PBS only) GADD153; CHOP; Growth arrest and DNA damage-inducible 153; C/EBP homologous protein; C/EBP Homology Protein; CEBPZ; CHOP10; DDIT 3; DNA Damage Inducible Transcript 3; GADD 153; Growth Arrest and DNA Damage Inducible Protein 153; Growth arrest and DNA damage inducible protein GADD153; MGC4154; DDIT3_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	DDIT3 Antibody is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to DDIT3.

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Ddit3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ddit3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddit3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddit3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ddit3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddit3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

DDIT3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DDIT3 Human Pre-designed siRNA Set A contains three designed siRNAs for DDIT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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