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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
GM2
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "GM2" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-16743
CAS No.: 1401090-53-6
Synonyms: Venglustat; SAR402671; GZ402671
Target:
Research Areas:
Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [2].
3
3 Cited Publications
Cat. No.: HY-16743A
CAS No.: 1629063-78-0
Synonyms: Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)
Target:
Research Areas:
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [2].
3
3 Cited Publications
Cat. No.: HY-16743B
CAS No.: 1629063-80-4
Synonyms: Venglustat succinate; SAR402671 succinate; GZ402671 succinate
Target:
Research Areas:
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [2].
Research Areas:
Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling [2] .
Cat. No.: HY-172546
Synonyms: LysoGM2 ammonium
Target:
Research Areas:
Lyso-monosialoganglioside GM2 (LysoGM2) ammonium is a lysosphingolipid and protein kinase C inhibitor (IC50: 50 μM). Lyso-monosialoganglioside GM2 ammonium can inhibit the binding of protein kinase C to Phorbol 12,13-dibutyrate (HY-18985). Lyso-monosialoganglioside GM2 ammonium is a specific biomarker for GM2 gangliosidosis. Lyso-monosialoganglioside GM2 ammonium can be used in the research of sphingolipidoses [2].
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Guanosine, 8-methyl-2′-O-methyl-
Synonyms: m8GM
Cat. No.: HY-W127461
CAS No.: 35960-33-9
Synonyms: Gangliotriosylceramide
Cat. No.: HY-171942A
Synonyms: C24:1-GM2 ammonium
Target:
Research Areas:
C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium) is an endogenous monosialylated ganglioside. C24:1 Ganglioside GM2 (d18:1/24:1) (ammonium) is a self-lipid that can bind to CD1d in HEK293T cells [2].
Cat. No.: HY-165676AS
CAS No.: 2750534-90-6
Synonyms: C16 GM2-dN; N-CDN-Palmitoyl-GM2, N-Hexadecaoyl-dN (13,13,14,14,15,15,16,16,16)-Moosialogaglioside GM2; N-Palmitoyl Moosialogaglioside GM2-d9
Cat. No.: HY-RS29483
Target:
Research Areas:
Gm2a Cattle Pre-designed siRNA Set A contains three designed siRNAs for Gm2a gene (Cattle), as well as a negative control, a positive control, and a FAM-labeled negative control.
Components
Gm2a siRNA-1: 5 nmol (HPLC)
Gm2a siRNA-2: 5 nmol (HPLC)
Gm2a siRNA-3: 5 nmol (HPLC)
siRNA Negative Control: 5 nmol (HPLC)
FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
GAPDH siRNA Positive Control: 5 nmol (HPLC)
Cat. No.: HY-167594S
Cat. No.: HY-N15906
CAS No.: 94458-61-4
Category:
Target:
Cat. No.: HY-171942
CAS No.: 3077081-42-3
Synonyms: C24:1-GM2
Target:
Research Areas:
C24:1 Ganglioside GM2 (d18:1/24:1) (C24:1-GM2) is a monosialylated ganglioside that contains nervonic acid.
Cat. No.: HY-152003S
CAS No.: 2692623-87-1
Cat. No.: HY-E70049
CAS No.: 67338-98-1
Synonyms: GM2/GD2 synthase
Target:
Research Areas:
beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides .
Cat. No.: HY-P991639
Cat. No.: HY-16743C
CAS No.: 1629063-79-1
Synonyms: Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride
Target:
Research Areas:
Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [2].
Cat. No.: HY-N15823
CAS No.: 3056013-74-9
Category:
Target:
Cat. No.: HY-RS05513
Target:
Research Areas:
GM2A Human Pre-designed siRNA Set A contains three designed siRNAs for GM2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24609
Target:
Research Areas:
Gm2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Gm2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
