35960-33-9
Chemical Structure
Ganglioside GM2, Asialo
Synonym(s): Gangliotriosylceramide
- CAS No.: 35960-33-9
- Formula:C56H104N2O18
- Molecular Weight:1093.43
IUPAC Name: N-((2S,3R,E)-1-(((2R,5S,6S)-5-(((2S,4R,5R)-5-(((2R,5R,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-
InChIKey: FOCMISOLVPZNSV-ZURMXPEJSA-N
SMILES: CCCCCCCCCCCCCCCCCC(N[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)CO[C@H]1C(O)C(O)[C@H](O[C@H]2C(O)[C@@H](O)[C@@H](O[C@@H]3C(NC(C)=O)C(O)[C@@H](O)[C@@H](O3)CO)C(O2)CO)[C@@H](O1)CO)=O
Biological Activity: Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.
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Ganglioside GM2, Asialo | Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length. | |||||||||||||||||||||
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Keywords
