127663-77-8
Chemical Structure
Ganglioside GM2
- CAS No.: 127663-77-8
- Formula:C67H121N3O26
- Molecular Weight:1384.68
InChIKey: GIVLTTJNORAZON-HDBOBKCLSA-N
SMILES: OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2O)O[C@@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)CO)CO)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O
Biological Activity: Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ganglioside GM2 | 98.17% | Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.96
HY-N15823C18:0 GM2(Neu5Gc) Ceramide (d18:1/18:0) -
Similarity Score 0.96
HY-171942C24:1 Ganglioside GM2 (d18:1/24:1) -
Similarity Score 0.96
HY-152003SGanglioside GM2-d3 ammonium -
Similarity Score 0.91
HY-171936Ganglioside GM1 ammonium -
Similarity Score 0.91
HY-179767C17:0 GM1 ammonium -
Similarity Score 0.91
HY-165650C16 Ganglioside GM1 (d18:1/16:0) -
Similarity Score 0.90
HY-179802C20:0 GM1 Ganglioside ammonium -
Similarity Score 0.89
HY-N15820C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0) -
Similarity Score 0.89
HY-N16333C18:0 GD2 Ceramide (d18:1/18:0) -
Explore the MedChemAI to find more analogs
References
- [1]. Kundu M, et al. Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1472-89. [Content Brief]
- [2]. Tai T, et al. Ganglioside GM2 as a human tumor antigen (OFA-I-1). Proc Natl Acad Sci U S A. 1983 Sep;80(17):5392-6. [Content Brief]
- [3]. Sandhoff K, et al. Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis. J Neurosci. 2013 Jun 19;33(25):10195-208. [Content Brief]
