Search Result

Results for "

GPR84 agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GPR84 (21) Aldose Reductase (1) Antibiotic (1) Bacterial (1) Enterovirus (1) ERK (1) Free Fatty Acid Receptor (4) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (18) Metabolic Disease (6) Neurological Disease (1)

Targets Recommended: GPR84 GPR39 G2A (GPR132) EBI2/GPR183 Kisspeptin Receptor Succinate Receptor 1 GPR55 GPR88 GPR171 GPR35 GPR119 GPR4 GPR139 GPR6 GPR65 GPR52 GPR68 GPR109A MCHR1 (GPR24) CX3CR1 Neuropeptide S Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12764

6-OAU 4 Publications Verification GTPL5846	GPR84 ERK Bacterial Antibiotic	Inflammation/Immunology
6-OAU (GTPL5846) (6-n-octylaminouracil) is an *GPR84* (G protein-coupled receptor 84) agonist, with an EC₅₀ value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function .

HY-124571

ZQ-16	GPR84	Inflammation/Immunology
ZQ-16 is a potent and selective *GPR84* agonist with an EC₅₀ value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120 .

HY-173556

GPR84 agonist-2	GPR84	Inflammation/Immunology
GPR84 agonist-2 is a selective *GPR84* agonist with no activity at free fatty acid receptors. GPR84 agonist-2 enhances GPR84-mediated signaling above basal levels and potentiates agonist-induced GPR84 activation. GPR84 agonist‑2 can be used for research on GPR84-related physiological mechanisms .

HY-100775

Fezagepras sodium 1 Publications Verification Setogepram sodium; PBI-4050 sodium	Free Fatty Acid Receptor GPR84	Metabolic Disease Inflammation/Immunology
Fezagepras (Setogepram) sodium acts as an orally active agonist for *GPR40* and as an antagonist or inverse agonist for *GPR84* . Fezagepras sodium decreases renal, liver and pancreatic fibrosis . Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .

HY-100775A

Fezagepras 1 Publications Verification Setogepram; PBI-4050	Free Fatty Acid Receptor GPR84	Metabolic Disease Inflammation/Immunology
Fezagepras (Setogepram) acts as an orally active agonist for *GPR40* and as an antagonist or inverse agonist for *GPR84* . Fezagepras decreases renal, liver and pancreatic fibrosis . Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .

HY-178234

LY237	GPR84	Inflammation/Immunology
LY237 is a highly efficient complete agonist of *GPR84* (pEC₅₀ = 10.15). LY237 can be used for research on inflammation and fibrosis conditions .

HY-161106

OX04528	GPR84	Inflammation/Immunology Cancer
OX04528 (compound 68) is a potent, G-protein biased, and orally active *GPR84* agonist. OX04528 no cytotoxicity. OX04528 inhibits cAMP production with an EC₅₀ value of 0.00598 nM .

HY-W182770

GPR84 agonist-1	GPR84	Inflammation/Immunology
GPR84 agonist-1 (Compound LY214-5) is a *GPR84* agonist, with an EC₅₀ of 2.479 μM. GPR84 agonist-1 can be used for the research of septicemia .

HY-126346

DL-175	GPR84	Inflammation/Immunology
DL-175 (compound 13) is a selective *GPR84* agonist with biased agonistic activity. DL-175 can selectively activate functional responses in immune cells and induce enhanced chemotaxis and phagocytosis of human bone marrow cells. DL-175 is a potential chemical probe .

HY-176039

TUG-2181	GPR84 Reactive Oxygen Species (ROS)	Inflammation/Immunology
TUG-2181 is an antagonist of *GPR84* with an IC₅₀ value of 34 nM. TUG-2181 inhibits GPR84 agonists-induced reactive species oxygen (ROS) production and IL-8 release in human neutrophils. TUG-2181 can be used for inflammation and fibrosis study .

HY-163350

TUG-2208	GPR84	Inflammation/Immunology
TUG-2208 (compound 42a) is a *GPR84* agonist (pEC₅₀=8.98) with low lipophilicity and good solubility, in vitro permeability and microsomal stability .

HY-171115

Pyrone-211	GPR84 Aldose Reductase	Metabolic Disease
Pyrone-211 is a potent *GPR84* agonist and AKR1C3 inhibitor. Pyrone-211 participates in an expanded polyamine pathway .

HY-179471

PSB-17365	GPR84	Inflammation/Immunology
PSB-17365 is a potent *GPR84* agonist with EC₅₀ values of 2.5 nM and 100 nM in a cAMP accumulation assay and a β-arrestin 2 recruitment assay, respectively .

HY-161107

OX04529	GPR84	Inflammation/Immunology
OX04529 (compound 69) is a potent, selective and orally active agonist of *GPR84. OX04529 inhibits FSK-induced cAMP production with an EC₅₀* of 0.0185 nM. OX04529 displayed excellent potency, high G-protein signaling bias .

HY-163349

TUG-2099	GPR84	Cardiovascular Disease Neurological Disease Cancer
TUG-2099 (compound 4s) is a potent *GPR84* agonist with the EC₅₀ of 0.3 nM. TUG-2099 can be used for study of Alzheimer’s disease, atherosclerosis, cancer, and so an .

HY-100775R

Fezagepras sodium (Standard) Setogepram sodium (Standard); PBI-4050 sodium (Standard)	Reference Standards Free Fatty Acid Receptor GPR84	Metabolic Disease Inflammation/Immunology
Fezagepras (sodium) (Standard) is the analytical standard of Fezagepras (sodium). This product is intended for research and analytical applications. Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84 . Fezagepras sodium decreases renal, liver and pancreatic fibrosis . Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .

HY-100775AR

Fezagepras (Standard) Setogepram (Standard); PBI-4050 (Standard)	Reference Standards Free Fatty Acid Receptor GPR84	Metabolic Disease Inflammation/Immunology
Fezagepras (Standard) is the analytical standard of Fezagepras. This product is intended for research and analytical applications. Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84 . Fezagepras decreases renal, liver and pancreatic fibrosis . Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .

HY-182921

GPR84 antagonist 11	GPR84 Enterovirus	Inflammation/Immunology
GPR84 antagonist 11 is a highly selective *GPR84* antagonist, with a human pA₂ of 8.41 and a pK_i of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of *GPR84* and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases .

HY-182723

PSB-16671	GPR84	Cancer
PSB-16671 is an allosteric agonist of *GPR84. PSB-16671 recruits β-arrestins and couples to Gi, enhances the Gi activation potency of orthosteric agonists, and exerts a synergistic effect with orthosteric agonists. PSB-16671 promotes G protein activation and partial chemotaxis independent of GPR84* in mouse neutrophils, maintains the phagocytic function of macrophages against cancer cells without inducing receptor desensitization. PSB-16671 can be used in cancer-related research .

HY-17669

PSB-16434	GPR84	Metabolic Disease Inflammation/Immunology
PSB-16434 is a selective G protein-coupled receptor 84 (GPR84) agonist. PSB-16434 is promising for research of inflammatory diseases, metabolic disorders, and immune regulation .

HY-167754

Resolvin D5 n-3 DPA	GPR84	Inflammation/Immunology
Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a *GPR101, GPR12, and GPR84* agonist with EC₅₀s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

We use cookies

MedChemExpress values your privacy and your trust is important to us. We use cookies to enhance your website experience. Some cookies are necessary to run the website. Privacy and Cookie Policy

Name
Email *

	Sorry, but the email address you supplied was invalid.

GPR84 agonist

Inhibitors & Agonists