83797-69-7
83797-69-7
Chemical Structure
6-OAU
Synonym(s): GTPL5846
- CAS No.: 83797-69-7
- Formula:C12H21N3O2
- Molecular Weight:239.31
IUPAC Name: 6-(octylamino)pyrimidine-2,4(1H,3H)-dione
InChIKey: PFSWASUQURIOOR-UHFFFAOYSA-N
SMILES: O=C1NC(C=C(NCCCCCCCC)N1)=O
Biological Activity: 6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function[1][2].
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6-OAU | 99.77% | 6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function. | ||||||||||||||||||||
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6-OAU (Standard) | ≥98% | 6-OAU (Standard) (GTPL5846 (Standard)) is the analytical standard of 6-OAU (HY-12764). This product is intended for research and analytical applications. 6-OAU (GTPL5846) (6-n-octylaminouracil) is an GPR84 (G protein-coupled receptor 84) agonist, with an EC50 value of 105 nM. 6-OAU works as a chemoattractant to both PMNs and macrophages, and amplifies the proinflammatory cytokine IL-8, shows proinflammatory function. 6-OAU also displays anti-bacterial function. | ||||||||||||||||||||
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References
- [1]. Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. [Content Brief]
- [2]. Reyes AWB, et al. Immune-metabolic receptor GPR84 surrogate and endogenous agonists, 6-OAU and lauric acid, alter Brucella abortus 544 infection in both in vitro and in vivo systems. Microb Pathog. 2021 Sep. 158:105079. [Content Brief]
