GPR84 antagonist 11
GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA2 of 8.41 and a pKi of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases.
For research use only. We do not sell to patients.
- Formula: C21H28N2O3
- Molecular Weight:356.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GPR84 antagonist 11 (Compound 42E2) is a moderately potent competitive orthosteric antagonist of mouse GPR84, with a pA2 value of 6.4[1].
GPR84 antagonist 11 exhibits no significant activity against FFAR1, FFAR2, FFAR3 or FFAR4, demonstrating remarkable selectivity for GPR84[1].
GPR84 antagonist 11 exhibits favorable solubility, logD, and plasma protein binding properties, but shows poor metabolic stability in mouse liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 356.46
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Formula C21H28N2O3
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SMILES
O=C(NCC1CCCCC1)[C@H]2[C@]3([H])COC4=CC=CC=C4[C@]3([H])N(C(C)=O)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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