GPR84 antagonist 11 

GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA₂ of 8.41 and a pK_i of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases^[1].

GPR84 antagonist 11 (Compound 42E2) is a moderately potent competitive orthosteric antagonist of mouse GPR84, with a pA₂ value of 6.4^[1].
GPR84 antagonist 11 exhibits no significant activity against FFAR1, FFAR2, FFAR3 or FFAR4, demonstrating remarkable selectivity for GPR84^[1].
GPR84 antagonist 11 exhibits favorable solubility, logD, and plasma protein binding properties, but shows poor metabolic stability in mouse liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

356.46

C₂₁H₂₈N₂O₃

O=C(NCC1CCCCC1)[C@H]2[C@]3([H])COC4=CC=CC=C4[C@]3([H])N(C(C)=O)C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Malone MA, et al. Discovery, Structure-Activity Relationship, and Functional Characterization of a Chromenopyrrole Series as Orthosteric Antagonists of GPR84. J Med Chem. 2026;69(7):7945-7965.