GPR84 antagonist 11
GPR84 antagonist 11 is a highly selective GPR84 antagonist, with a human pA2 of 8.41 and a pKi of 8.16. GPR84 antagonist 11 competitively inhibits the binding of agonists to the orthosteric site of GPR84 and has improved druglike properties, though its metabolic stability still requires optimization. GPR84 antagonist 11 can be used in the research of autoimmune diseases and fibrotic diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C21H28N2O3
- Peso molecular:356.46
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
GPR84 antagonist 11 (Compound 42E2) is a moderately potent competitive orthosteric antagonist of mouse GPR84, with a pA2 value of 6.4[1].
GPR84 antagonist 11 exhibits no significant activity against FFAR1, FFAR2, FFAR3 or FFAR4, demonstrating remarkable selectivity for GPR84[1].
GPR84 antagonist 11 exhibits favorable solubility, logD, and plasma protein binding properties, but shows poor metabolic stability in mouse liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Peso molecular 356.46
-
Fòrmula C21H28N2O3
-
SMILES
O=C(NCC1CCCCC1)[C@H]2[C@]3([H])COC4=CC=CC=C4[C@]3([H])N(C(C)=O)C2
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPR84 antagonist 11 Related Classifications
HY-182921 Related Classifications
Powered by Bioz