2. GPCR/G Protein
  3. GPR84
  4. LY237

LY237 is a highly efficient complete agonist of GPR84 (pEC50 = 10.15). LY237 can be used for research on inflammation and fibrosis conditions.

For research use only. We do not sell to patients.

LY237

LY237 Chemical Structure

CAS No. : 1892576-07-6

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Based on 1 publication(s) in Google Scholar

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Description

LY237 is a highly efficient complete agonist of GPR84 (pEC50 = 10.15). LY237 can be used for research on inflammation and fibrosis conditions[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.00018 μM
Compound: 51
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Galpha16 protein by Fluo-4 AM dye based calcium mobilization assay
[PMID: 27326330]
HEK293 EC50
0.352 nM
Compound: 51
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin addition measured after 30 mins by HTRF assay
[PMID: 27326330]
Molecular Weight

237.34

Formula

C14H23NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C=C(CCCCCCCCC)N1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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LY237 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY2371892576-07-6LY 237LY-237GPR84G protein coupled receptor 84agonistinflammationfibrosisInhibitorinhibitorinhibit

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HY-178234
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