2094630-35-8
Chemical Structure
PSB-16671
- CAS No.: 2094630-35-8
- Formula:C17H10F4N2
- Molecular Weight:318.27
InChIKey: VOZFGFKTXNHCLF-UHFFFAOYSA-N
SMILES: FC1=CC2=C(NC=C2CC3=CNC4=C3C=C(F)C=C4F)C(F)=C1
Biological Activity: PSB-16671 is an allosteric agonist of GPR84. PSB-16671 recruits β-arrestins and couples to Gi, enhances the Gi activation potency of orthosteric agonists, and exerts a synergistic effect with orthosteric agonists. PSB-16671 promotes G protein activation and partial chemotaxis independent of GPR84 in mouse neutrophils, maintains the phagocytic function of macrophages against cancer cells without inducing receptor desensitization. PSB-16671 can be used in cancer-related research[1][2][3].
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PSB-16671 | PSB-16671 is an allosteric agonist of GPR84. PSB-16671 recruits β-arrestins and couples to Gi, enhances the Gi activation potency of orthosteric agonists, and exerts a synergistic effect with orthosteric agonists. PSB-16671 promotes G protein activation and partial chemotaxis independent of GPR84 in mouse neutrophils, maintains the phagocytic function of macrophages against cancer cells without inducing receptor desensitization. PSB-16671 can be used in cancer-related research. | |||||||||||||||||||||
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- [1]. Mancini SJ, et al. On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Sci Rep. 2019;9(1):1861. Published 2019 Feb 12. [Content Brief]
- [2]. Pillaiyar T, et al. Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84. J Med Chem. 2017;60(9):3636-3655. [Content Brief]
- [3]. Zhang X, et al. Mechanism of GPR84 allosteric modulation at a helix 8-proximate site. bioRxiv [Preprint]. 2026 Apr 12:2026.04.10.715585. [Content Brief]
Keywords
