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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
GSDME
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "GSDME" in MCE Product Catalog:
23
23 Publications Verification
Synonyms: 2-Bromopalmitic acid; 2-Bromopalmitate
Target:
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2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis .
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Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .
Cat. No.: HY-P10939A
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Cat. No.: HY-RS05858
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GSDME Human Pre-designed siRNA Set A contains three designed siRNAs for GSDME gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16846
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Research Areas:
Gsdme Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gsdme gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10939
CAS No.: 2588354-33-8
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Cat. No.: HY-175381
CAS No.: 3058911-16-0
Research Areas:
DeFer-2 is a ferritin PROTAC degrader (Kd = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma .
Cat. No.: HY-B0621R
CAS No.: 68786-66-3
Synonyms: CGA89317 (Standard)
Research Areas:
Triclabendazole (Standard) is the analytical standard of Triclabendazole. This product is intended for research and analytical applications. Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .
Cat. No.: HY-N15380
CAS No.: 2265910-52-7
Cat. No.: HY-RS23287
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Gsdme Rat Pre-designed siRNA Set A contains three designed siRNAs for Gsdme gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-B0621S
CAS No.: 1353867-93-2
Synonyms: CGA89317-d3
Cat. No.: HY-P80697A
Synonyms: DFNA5; ICERE-1; GSDME
Cat. No.: HY-P704047
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Inversely correlated with estrogen receptor expression 1
Cat. No.: HY-181005
Research Areas:
FGFR-IN-25 (Compound 19E) is a FGFR inhibitor (IC50s: 1.30 nM and 0.85 nM for FGFR1 and FGFR2, respectively) and radiosensitizer. FGFR-IN-25 effectively reduces the phosphorylation of FGFR1 and its key downstream effectors, pAKT and pERK. FGFR-IN-25 exerts broad-spectrum antitumor activity against gastric cancer, colorectal carcinoma, hepatocellular carcinoma, breast cancer, triple-negative breast cancer, and glioblastoma. FGFR-IN-25, when combined with radiotherapy, synergistically activates the ROS-Caspase-3-GSDME axis, downregulates PD-L1 expression, and induces immunogenic cell death (ICD). FGFR-IN-25 combined with radiotherapy improves the antitumor efficacy .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
