3058911-16-0
Chemical Structure
DeFer-2
- CAS No.: 3058911-16-0
- Formula:C44H69N5O5S
- Molecular Weight:780.11
IUPAC Name: (2S,4R)-1-((S)-3,3-dimethyl-2-(4-oleamidobutanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: FOJJJSRIPHLZFB-HJBYGEKRSA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)=O)=O
Biological Activity: DeFer-2 is a ferritin PROTAC degrader (Kd = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DeFer-2 | 98.25% | DeFer-2 is a ferritin PROTAC degrader (Kd = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. | ||||||||||||||||||||
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Keywords
