2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Cell Cycle/DNA Damage Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. FGFR Akt PERK Reactive Oxygen Species (ROS) Caspase Pyroptosis PD-1/PD-L1
  4. FGFR-IN-25

FGFR-IN-25 (Compound 19E) is a FGFR inhibitor (IC50s: 1.30 nM and 0.85 nM for FGFR1 and FGFR2, respectively) and radiosensitizer. FGFR-IN-25 effectively reduces the phosphorylation of FGFR1 and its key downstream effectors, pAKT and pERK. FGFR-IN-25 exerts broad-spectrum antitumor activity against gastric cancer, colorectal carcinoma, hepatocellular carcinoma, breast cancer, triple-negative breast cancer, and glioblastoma. FGFR-IN-25, when combined with radiotherapy, synergistically activates the ROS-Caspase-3-GSDME axis, downregulates PD-L1 expression, and induces immunogenic cell death (ICD). FGFR-IN-25 combined with radiotherapy improves the antitumor efficacy.

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FGFR-IN-25

FGFR-IN-25 Chemical Structure

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FGFR-IN-25 Related Antibodies

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Description

FGFR-IN-25 (Compound 19E) is a FGFR inhibitor (IC50s: 1.30 nM and 0.85 nM for FGFR1 and FGFR2, respectively) and radiosensitizer. FGFR-IN-25 effectively reduces the phosphorylation of FGFR1 and its key downstream effectors, pAKT and pERK. FGFR-IN-25 exerts broad-spectrum antitumor activity against gastric cancer, colorectal carcinoma, hepatocellular carcinoma, breast cancer, triple-negative breast cancer, and glioblastoma. FGFR-IN-25, when combined with radiotherapy, synergistically activates the ROS-Caspase-3-GSDME axis, downregulates PD-L1 expression, and induces immunogenic cell death (ICD). FGFR-IN-25 combined with radiotherapy improves the antitumor efficacy[1].

IC50 & Target[1]

Caspase 3

 

FGFR1

1.30 nM (IC50)

FGFR2

0.85 nM (IC50)

Molecular Weight

669.82

Formula

C36H47N9O4
SMILES

COC1=CC(OC)=CC(N(C2=CC=C3N=CC(C4=CN(N=C4)CCCCCCCCN5C(C)=NC=C5[N+]([O-])=O)=NC3=C2)CCNC(C)C)=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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FGFR-IN-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-25FGFRAktPERKReactive Oxygen Species (ROS)CaspasePyroptosisPD-1/PD-L1Fibroblast growth factor receptorPKBProtein kinase BProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePD-1/Programmed death-ligand 1gastric cancercolorectal carcinomahepatocellular carcinomabreast cancertriple-negative breast cancerand glioblastomaInhibitorinhibitorinhibit

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