17 Results for "

Gypenosides

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "Gypenosides" in MCE Product Catalog:

4
Gypenoside L
Gypenoside L
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4 Cited Publications
Cat. No.: HY-N8211
CAS No.: 94987-09-4
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Inflammation/Immunology Gynostemma pentaphyllum (Thunb.) Makino

Target:  

p38 MAPK ERK NF-κB

Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities .
3
Gypenoside XVII
Gypenoside XVII
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3 Cited Publications
Cat. No.: HY-N0553
CAS No.: 80321-69-3
Synonyms: Gynosaponin S
Category:  

Cardiovascular Disease Triterpenes Terpenoids Cucurbitaceae Plants Endogenous metabolite Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Estrogen Receptor/ERR Endogenous Metabolite

Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.
2
Gypenoside XLIX
Gypenoside XLIX
0 Images
2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
Category:  

Cardiovascular Disease Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy

Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a Ka value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .
1
Gypenoside A
Gypenoside A
0 Images
1 Cited Publications
Cat. No.: HY-N2440
CAS No.: 157752-01-7
Category:  

Triterpenes Terpenoids Cucurbitaceae Metabolic Disease Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Interleukin Related Reactive Oxygen Species (ROS) AMPK FOXO COX Apoptosis

Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases .
1
Gynostemma Extract
Gynostemma Extract
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1 Cited Publications
Cat. No.: HY-N0167
CAS No.: 80321-63-7
Synonyms: Ginsenoside C-Mx1; Gypenoside IX
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Endogenous metabolite Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase

Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .
1
Gypenoside LI
Gypenoside LI
0 Images
1 Cited Publications
Cat. No.: HY-N8207
CAS No.: 94987-10-7
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

Apoptosis MicroRNA

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration .
1
Gypenoside XIII
Gypenoside XIII
0 Images
1 Cited Publications
Cat. No.: HY-N6881
CAS No.: 80325-22-0
Category:  

Cardiovascular Disease Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Others

Gypenoside XIII is belonging to the gypenosides. Gypenosides, extracted from Gynostemma pentaphyllum, have various pharmacological properties and protect against cardiovascular diseases, especially atherosclerosis .
1
Gypenoside LXXV
Gypenoside LXXV
0 Images
1 Cited Publications
Cat. No.: HY-N7678
CAS No.: 110261-98-8
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Araliaceae Cancer

Target:  

Others

Gypenoside LXXV, isolated from Gynostemma pentaphyllum, is one of the deglycosylated shapes of ginsenoside Rb1. Gypenoside LXXV significantly reduces cancer cell viability and displays an anti-cancer effect .
1
Gypenoside XLVI
Gypenoside XLVI
0 Images
1 Cited Publications
Cat. No.: HY-N6252
CAS No.: 94705-70-1
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

Others

Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .
Gypenoside XVII (Standard)
Gypenoside XVII (Standard)
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Cat. No.: HY-N0553R
CAS No.: 80321-69-3
Synonyms: Gynosaponin S (Standard)
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Endogenous metabolite Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Reference Standards Estrogen Receptor/ERR Endogenous Metabolite

Gypenoside XVII (Standard) is the analytical standard of Gypenoside XVII. This product is intended for research and analytical applications. Gypenoside XVII, a novel phytoestrogen belonging to the gypenosides, can activate estrogen receptors.
2-Methylanisole (Standard)
2-Methylanisole (Standard)
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Cat. No.: HY-W027751R
CAS No.: 578-58-5
Target:  

Drug Intermediate Reference Standards

Domaines de recherche:  

Others

Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
Gypenoside XLIX (Standard)
Gypenoside XLIX (Standard)
0 Images
Cat. No.: HY-N1990R
CAS No.: 94987-08-3
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Reference Standards PPAR

Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
Gypenoside UL5
Gypenoside UL5
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Cat. No.: HY-N17992
CAS No.: 1443433-27-9
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Others

Gypenoside UL5 (Compound UL5) is a dammarane-type triterpene saponin found in Gynostemma pentaphyllum. Gypenoside UL5 shows liver injury-inhibiting, anti-inflammatory and antioxidant properties. Gypenoside UL5 can be used for the research of hepatitis, fatty liver, and liver fibrosis .
21-keto-Gypenoside A
21-keto-Gypenoside A
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Cat. No.: HY-N17207
CAS No.: 1392136-41-2
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino

Target:  

Drug Derivative

21-keto-Gypenoside A is a natural triterpene.
Gypenoside XCI
Gypenoside XCI
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Cat. No.: HY-N17991
CAS No.: 2793436-99-2
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino

Gypenoside XCI is a glycoside found in Gynostemma pentaphyllum .
Gypenoside CII
Gypenoside CII
0 Images
Cat. No.: HY-N18048
CAS No.: 134355-16-1
Category:  

Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Steroids

Target:  

Sirtuin

Gypenoside CII is a dammarane-type triterpene saponin that can be isolated from Gynostemma pentaphyllum. Gypenoside CII exerts no significant activating effect on recombinant human Sirt1, while its congeners are potent Sirt1 agonists .
Gypenoside LXIX
Gypenoside LXIX
0 Images
Cat. No.: HY-N18005
CAS No.: 109150-50-7
Category:  

Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Steroids

Target:  

Others

Gypenoside LXIX (Compound 4) is a glycoside found in the aerial parts of Gynostemma pentaphyllum .
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Assay Types