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Hawthorn

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By Targets:	Akt (1) AMPK (1) Apoptosis (1) Bcl-2 Family (1) Caspase (1) Cholinesterase (ChE) (2) Elastase (1) Endogenous Metabolite (1) Glycosidase (1) Interleukin Related (1) PI3K (1) Reference Standards (1) SOD (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (4) Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-177475

LysoPC(20:4) 1-Arachidonoyl-sn-glycero-3-phosphocholine	Endogenous Metabolite	Metabolic Disease Cancer
LysoPC 20:4 (20:4) (1-Arachidonoyl-sn-glycero-3-phosphocholine) is a serum metabolite. LysoPC 20:4 (20:4) decreases in tumor-bearing mice, but the reduction is not significant. LysoPC (20:4) can be used in cancer and obesity-related research .

HY-N4142

Cyanidin-3-O-galactoside chloride 4 Publications Verification Ideain chloride	Cholinesterase (ChE)	Cardiovascular Disease
Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

HY-N13250

Hawthorn Extract	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD	Cardiovascular Disease
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases Bcl-2 expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, Elastase release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension .

HY-N4142R

Cyanidin-3-O-galactoside chloride (Standard) Ideain chloride (Standard)	Reference Standards Cholinesterase (ChE)	Cardiovascular Disease
Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

HY-120977

Methyl pentacosanoate	Others	Others
Methyl pentacosanoate can be isolated from hawthorn leaves .

HY-N7709

Cinchonain IIb	Others	Cardiovascular Disease
Cinchonain IIb is a proanthocyanidin. Cinchonain IIb has the effect of rational utilization of decreased cardiac function. Cinchonain IIb is isolated from natural hawthorn (Crataegus spp. ) .

HY-N17717

Vitexin-2''-O-glucoside Flavosativaside	Glycosidase	Metabolic Disease
Vitexin-2''-O-glucoside (Flavosativaside) is a potent and selective alpha-glucosidase inhibitor found in hawthorn leaf flavonoids. Vitexin-2''-O-glucoside can reversibly inhibit the α-glucosidase activity on the brush border of the small intestine, and its inhibitory effect is superior to that of the Acarbose (HY-B0089). Vitexin-2''-O-glucoside can be used for the research of type 2 diabetes .

Cyanidin-3-O-galactoside chloride 4 Publications Verification Ideain chloride	Cardiovascular Disease Anthocyans Flavonoids Classification of Application Fields Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Disease Research Fields Source Classification	Cholinesterase (ChE)
Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

Hawthorn Extract	Cardiovascular Disease Classification of Application Fields Rosaceae Plants Disease Research Fields Source Classification	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases Bcl-2 expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, Elastase release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension .

Cyanidin-3-O-galactoside chloride (Standard) Ideain chloride (Standard)	Structural Classification Anthocyans Flavonoids Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Source Classification	Reference Standards Cholinesterase (ChE)
Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity .

Methyl pentacosanoate	Natural Products Centaurea aspera stenophylla Plants Compositae Source Classification	Others
Methyl pentacosanoate can be isolated from hawthorn leaves .

Cinchonain IIb	Crataegus monogyna Jacq. Rosaceae Phenols Polyphenols Plants Source Classification	Others
Cinchonain IIb is a proanthocyanidin. Cinchonain IIb has the effect of rational utilization of decreased cardiac function. Cinchonain IIb is isolated from natural hawthorn (Crataegus spp. ) .

Vitexin-2''-O-glucoside Flavosativaside	Structural Classification Flavonoids Flavones Piper umbellatum L. Piperaceae Plants Source Classification	Glycosidase
Vitexin-2''-O-glucoside (Flavosativaside) is a potent and selective alpha-glucosidase inhibitor found in hawthorn leaf flavonoids. Vitexin-2''-O-glucoside can reversibly inhibit the α-glucosidase activity on the brush border of the small intestine, and its inhibitory effect is superior to that of the Acarbose (HY-B0089). Vitexin-2''-O-glucoside can be used for the research of type 2 diabetes .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Hawthorn

Inhibitors & Agonists

NaturalProducts

Natural
Products