46 Results for "

ICER

" in MedChemExpress (MCE) Product Catalog:
Products (46)

46 Results for "ICER" in MCE Product Catalog:

755
Z-VAD-FMK
Z-VAD-FMK
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755 Publications Verification
Cat. No.: HY-16658B
CAS No.: 161401-82-7
Synonyms: Z-VAD(OH)-FMK
Target:  

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Domaines de recherche:  

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
172
Belnacasan
Belnacasan
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172 Cited Publications
Cat. No.: HY-13205
CAS No.: 273404-37-8
Pureté:  99.99%
Synonyms: VX-765
Target:  

Caspase

Domaines de recherche:  

Inflammation/Immunology

Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
34
Ac-YVAD-cmk
Ac-YVAD-cmk
0 Images
34 Cited Publications
Cat. No.: HY-16990
CAS No.: 178603-78-6
Synonyms: Caspase-1 Inhibitor II
Target:  

Caspase

Domaines de recherche:  

Inflammation/Immunology

Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .
6
Skatole
Skatole
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6 Cited Publications
Cat. No.: HY-W007355
CAS No.: 83-34-1
Synonyms: 3-Methylindole; 3-Methyl-1H-indole
Category:  

Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Environmental Pollutants Apoptosis Endogenous Metabolite p38 MAPK Aryl Hydrocarbon Receptor

Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .
5
VRT-043198
VRT-043198
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5 Cited Publications
Cat. No.: HY-112226
CAS No.: 244133-31-1
Pureté:  98.89%
Target:  

Caspase Drug Metabolite

Domaines de recherche:  

Inflammation/Immunology

VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively .
1
Pralnacasan
Pralnacasan
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1 Cited Publications
Cat. No.: HY-19676
CAS No.: 192755-52-5
Synonyms: VX-740; HMR 3480
Target:  

Caspase

Domaines de recherche:  

Inflammation/Immunology

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment .
Ac-YVAD-CHO
Ac-YVAD-CHO
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Cat. No.: HY-120019
CAS No.: 143313-51-3
Pureté:  98.23%
Synonyms: L-709049
Target:  

Interleukin Related Apoptosis Caspase

Domaines de recherche:  

Inflammation/Immunology

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .
Geranylgeranoic acid
Geranylgeranoic acid
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Cat. No.: HY-156202
CAS No.: 35750-48-2
Target:  

Histone Demethylase PD-1/PD-L1 Apoptosis

Domaines de recherche:  

Cancer

Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC50 value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis .
Cycleanine
Cycleanine
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Cat. No.: HY-N2005
CAS No.: 518-94-5
Category:  

Alkaloids Plants Cissampelos pareira Disease Research Fields Inflammation/Immunology Menispermaceae Alkaloid Dimers

Target:  

Calcium Channel Apoptosis

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway .
2,3-Pentanedione
2,3-Pentanedione
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Cat. No.: HY-W012998
CAS No.: 600-14-6
Category:  

other families Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields

Target:  

Drug Intermediate

2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
Antifreeze Polypeptide 6 (winter flounder)
Antifreeze Polypeptide 6 (winter flounder)
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Cat. No.: HY-P3832
CAS No.: 122604-16-4
Target:  

Peptides

Domaines de recherche:  

Others

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei .
Skatole (Standard)
Skatole (Standard)
0 Images
Cat. No.: HY-W007355R
CAS No.: 83-34-1
Synonyms: 3-Methylindole (Standard); 3-Methyl-1H-indole (Standard)
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite

Target:  

Reference Standards Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis

Skatole (Standard) is the analytical standard of Skatole. This product is intended for research and analytical applications. Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .
ICeD-2
ICeD-2
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Cat. No.: HY-151871
CAS No.: 3050598-72-3
Target:  

Dipeptidyl Peptidase HIV

Domaines de recherche:  

Infection

ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by dipeptidyl peptidase DPP8 and DPP9. ICeD-2 shows strong stabilization of DPP9 in PBMCs .
2,3-Pentanedione (Standard)
2,3-Pentanedione (Standard)
0 Images
Cat. No.: HY-W012998R
CAS No.: 600-14-6
Category:  

other families Microorganisms Ketones, Aldehydes, Acids Plants

Target:  

Reference Standards Biochemical Assay Reagents

2,3-Pentanedione (Standard) is the analytical standard of 2,3-Pentanedione. This product is intended for research and analytical applications. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans .
1-Nonadecanol
1-Nonadecanol
0 Images
Cat. No.: HY-W004297
CAS No.: 1454-84-8
Category:  

Natural Products other families Other Diseases Plants Disease Research Fields

Target:  

Endogenous Metabolite Bacterial

1-Nonadecanol is an endogenous metabolite that can be produced by Pantoea agglomerans from Medicago sativa rhizosphere, present in Neotinea ustulata scent and Heracleum thomsonii essential oil. 1-Nonadecanol exerts antimicrobial activity against Streptococcus pneumonia, Klebsiella, and S. aureus. 1-Nonadecanol can be used for the research of bacterial infections and pea aphid infestation .
Belnacasan (Standard)
Belnacasan (Standard)
0 Images
Cat. No.: HY-13205R
CAS No.: 273404-37-8
Synonyms: VX-765 (Standard)
Target:  

Caspase Reference Standards

Domaines de recherche:  

Inflammation/Immunology

Belnacasan (Standard) is the analytical standard of Belnacasan. This product is intended for research and analytical applications. Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
YVAD-CHO
YVAD-CHO
0 Images
Cat. No.: HY-P5890
CAS No.: 153604-27-4
Target:  

Interleukin Related Caspase

Domaines de recherche:  

Neurological Disease Inflammation/Immunology

YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM). YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice .
YVAD-CHO TFA
YVAD-CHO TFA
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Cat. No.: HY-P5890A
Target:  

Caspase Interleukin Related

Domaines de recherche:  

Neurological Disease Inflammation/Immunology

YVAD-CHO TFA is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM). YVAD-CHO TFA inhibits mature IL-1β production. YVAD-CHO TFA partially delays motoneurone death in lesioned facial nerve mice .
Ac-YVAD-CHO acetate
Ac-YVAD-CHO acetate
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Cat. No.: HY-120019A
Synonyms: L-709049 acetate
Target:  

Interleukin Related Caspase Apoptosis

Domaines de recherche:  

Inflammation/Immunology

Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ .
Ethyl butyrylacetate
Ethyl butyrylacetate
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Cat. No.: HY-W015487
CAS No.: 3249-68-1
Synonyms: Ethyl 3-oxohexanoate
Ethyl butyrylacetate is an organic compound belonging to the class of esters. Synthesized by the reaction of ethyl acetate, butyric acid and acetic anhydride. Ethyl butyrylacetate has a fruity aroma and is commonly used as a flavoring agent in various food and beverages such as candies, ice cream and soft drinks. It is also used as a fragrance ingredient in perfumes and personal care products. In addition to its use in the food and fragrance industries, Ethyl butyrylacetate is also used in industrial settings, such as in the production of solvents.
Assay Types