153604-27-4
153604-27-4
Chemical Structure
YVAD-CHO
- CAS No.: 153604-27-4
- Formula:C21H30N4O7
- Molecular Weight:450.49
InChIKey: HWLANCVZPRATJR-GKEYINFOSA-N
SMILES: O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C=O)=O)=O)[C@H](CC1=CC=C(C=C1)O)N
Biological Activity: YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM). YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice[1][2].
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YVAD-CHO | YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor (Ki: 0.76 nM). YVAD-CHO inhibits mature IL-1β production. YVAD-CHO partially delays motoneurone death in lesioned facial nerve mice. | |||||||||||||||||||||
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References
- [1]. de Bilbao F, Dubois-Dauphin M. Acute application of an interleukin-1 beta-converting enzyme-specific inhibitor delays axotomy-induced motoneurone death. Neuroreport. 1996 Nov 25;7(18):3051-4. [Content Brief]
- [2]. Laliberte RE, et al. ATP treatment of human monocytes promotes caspase-1 maturation and externalization. J Biol Chem. 1999 Dec 24;274(52):36944-51. [Content Brief]
Keywords
