2. Peptides
  3. Antifreeze Polypeptide 6 (winter flounder)

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei.

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Antifreeze Polypeptide 6 (winter flounder) Chemical Structure

Antifreeze Polypeptide 6 (winter flounder) Chemical Structure

CAS No. : 122604-16-4

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Antifreeze Polypeptide 6 (winter flounder) Related Antibodies

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Description

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei[1].

In Vitro

Antifreeze Polypeptide 6 (winter flounder) inhibits the growth of ice crystals by hydrogen bonding of Thr, Asn, and Asp side chains in a specific pattern to the hexagonal bipyramidal planes of ice. This mode of binding is unidirectional, maximizing opportunities for packing of AFPs on the ice surface, and that ice crystal growth inhibition occurs by a two-step mechanism involving hydrogen bonding and hydrophobic interpeptide interactions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifreeze Polypeptide 6 (winter flounder) Related Antibodies
Molecular Weight

3242.47

Formula

C133H225N43O51
CAS No.
Sequence Shortening

DTASDAAAAAALTAANAKAAAELTAANAAAAAAATAR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifreeze Polypeptide 6 (winter flounder)122604-16-4Otherswinter flounderice nucleiInhibitorinhibitorinhibit

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Antifreeze Polypeptide 6 (winter flounder)
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