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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
IMP dehydrogenase
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "IMP dehydrogenase" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: NSC 286193; Riboxamide
Research Areas:
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer .
Cat. No.: HY-129972
CAS No.: 66983-94-6
Synonyms: RMP dilithium
Category:
Target:
Target:
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T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
Cat. No.: HY-161712
CAS No.: 2427862-70-0
IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers .
Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Target:
Research Areas:
Xanthosine-5'-monophosphate can be obtained by catalyzing inosine 5'-monophosphate (IMP) with inosine 5'-monophosphate dehydrogenase (IMPDH) .
Cat. No.: HY-10250
CAS No.: 61966-08-3
Synonyms: TCN-P
Target:
Research Areas:
Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
Cat. No.: HY-136498
CAS No.: 356783-08-9
Target:
Research Areas:
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM .
Cat. No.: HY-P3820
Target:
Research Areas:
Cat. No.: HY-10250A
Purity: 99.82%
Synonyms: TCN-P sodium
Target:
Research Areas:
Triciribine phosphate sodium inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate sodium also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
Cat. No.: HY-118061
CAS No.: 1278553-16-4
VCC234718 is a molecule with mycobacterial growth inhibitory activity, specifically targeting Mycobacterium tuberculosis (Mtb). The primary molecular target of VCC234718 is inosine monophosphate dehydrogenase (GuaB2), and it inhibits the growth of Mtb by affecting the function of this enzyme. VCC234718 inhibits GuaB2 with a K value of 100 nM and exhibits non-competitive inhibition with IMP and NAD+. VCC234718 exerts its inhibitory effect by directly interacting with IMP and binding at the NAD+ site .
Cat. No.: HY-P702799
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IMPDH2; IMPD2; Inosine Monophosphate dehydrogenase 2; IMP (Inosine Monophosphate) dehydrogenase 2; IMP (Inosine 5'-Monophosphate) dehydrogenase 2; Epididymis Secretory Sperm Binding Protein; Inosine-5'-Monophosphate dehydrogenase Type II; Inosine-5'-Monop
Cat. No.: HY-P703151
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: IMPDH1; IMPD 1; Prev. RP10; IMPD; SWSS2608; Retinitis Pigmentosa 10 (Autosomal Dominant); LCA11; IMP (Inosine Monophosphate) dehydrogenase 1; IMP (Inosine 5'-Monophosphate) dehydrogenase 1; Inosine-5'-Monophosphate dehydrogenase; Inosine-5'-Monophosphate
Inosine-5'-monophosphate dehydrogenase, Microorganism (EC 1.1.1.205) catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
