19 Results for "

KV4.2

" in MedChemExpress (MCE) Product Catalog:
Products (19)

19 Results for "KV4.2" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-108588
CAS No.: 426834-69-7
Purity:  99.92%
Target:  

Potassium Channel

Research Areas:  

Cardiovascular Disease

NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2 .
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Cat. No.: HY-108574
CAS No.: 478341-55-8
Purity:  99.61%
Research Areas:  

Neurological Disease

CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl -). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels .
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Cat. No.: HY-P5785A
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

Heteropodatoxin-2 (TFA), a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials .
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Cat. No.: HY-P5786
Synonyms: HpTx1
Research Areas:  

Neurological Disease

Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8 .
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Cat. No.: HY-P2786A
CAS No.: 741738-57-8
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

Phrixotoxin 2 is a Kv4 family potassium channel inhibitor, with Ki values in rats of 120 nM for Kv4.2, 110 nM for Kv4.3, and 230 nM for Kv4.1. Phrixotoxin 2 mediates voltage-dependent inhibition of Kv4.2 and Kv4.3 currents, and voltage-independent inhibition of Kv4.1 currents. Phrixotoxin 2 fails to inhibit A-type K + currents in visceral dorsal root ganglion neurons. Phrixotoxin 2 induces contraction of non-pregnant uterine smooth muscle and triggers orofacial cold hyperalgesia in rats. Phrixotoxin 2 can distinguish the contribution of Kv4 subunits to A-type K + currents in different subsets of sensory neurons. Phrixotoxin 2 can be used in research related to chronic pain and trigeminal neuropathic pain .
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Cat. No.: HY-P5785
CAS No.: 741730-12-1
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

Heteropodatoxin-2, a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials .
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Cat. No.: HY-P5155
CAS No.: 741738-59-0
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats .
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Cat. No.: HY-P5770
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC50 of 604.2 nM) .
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Cat. No.: HY-P1426
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

AmmTX3 is a peptide toxin identified from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is a highly specific blocker of Kv4 channels, which selectively and almost completely blocks transient A-type K + currents with a Ki of 131 nM. AmmTX3 induces epileptiform behaviors and causes death in mice receiving intracerebroventricular injection. AmmTX3 increases the excitability of dentate gyrus granule cells, reduces GABAergic inhibition, enhances and stabilizes the EPSP-spike component of long-term potentiation, and impairs reference memory. AmmTX3 can be used in research related to pain, epilepsy, and autism spectrum disorder .
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Cat. No.: HY-P5873
Synonyms: JZTX-X
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-X (JZTX-X) is a selective Kv4.2 and Kv4.3 potassium channels inhibitor. Jingzhaotoxin-X causes long-lasting mechanical hyperalgesia .
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Cat. No.: HY-114540
CAS No.: 185855-91-8
Research Areas:  

Neurological Disease

CP-339818 is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl -). CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels .
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Cat. No.: HY-RS07113
Research Areas:  

Others

KCND2 Human Pre-designed siRNA Set A contains three designed siRNAs for KCND2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-108588R
CAS No.: 426834-69-7
NS5806 (Standard) is the analytical standard of NS5806 (HY-108588). This product is intended for research and analytical applications. NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2 .
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Cat. No.: HY-P5157
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells .
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Cat. No.: HY-P87415
Synonyms: Kiaa1044, MNCb-7013, Kcnd2, A-type voltage-gated potassium channel KCND2, Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit KV4.2

Host:  

Mouse

Application:  

FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P87415A
Synonyms: Kiaa1044, MNCb-7013, Kcnd2, A-type voltage-gated potassium channel KCND2, Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit KV4.2

Host:  

Mouse

Application:  

FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P86936
Synonyms: KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_HUMAN antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_HUMAN antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; RK5 antibody; Voltage gated potassium channel KV4.2 antibody; Voltage gated potassium channel subunit KV4.2 antibody; Voltage sensitive potassium channel antibody; Voltage-gated potassium channel subunit KV4.2 antibody;

Host:  

Mouse

Application:  

IHC-F, IHC-P, WB

Reactivity:  

Mouse, Rat

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Cat. No.: HY-RS21609
Research Areas:  

Others

Kcnd2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kcnd2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS28127
Research Areas:  

Others

Kcnd2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnd2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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