1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. NS5806

NS5806 

Cat. No.: HY-108588 Purity: >98.0%
Handling Instructions

NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2.

For research use only. We do not sell to patients.

NS5806 Chemical Structure

NS5806 Chemical Structure

CAS No. : 426834-69-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 379 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2[1].

IC50 & Target

IC50: 5.3 nM (KV4.3)[1]

In Vitro

NS5806 (10 µM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 µM in CHO-K1 cells[1].
NS5806 activates canine transient outward potassium current (Ito) with an IC50 of 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on rabbit, respectively[2].
NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito[2].

Molecular Weight

574.07

Formula

C₁₆H₈Br₂F₆N₆O

CAS No.

426834-69-7

SMILES

O=C(NC1=C(C2=NNN=N2)C=C(Br)C=C1Br)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

NS5806NS 5806NS-5806Potassium ChannelKcsAKV4.3KChIP2peakcurrentamplitudesKV4.2dacayIto,Inhibitorinhibitorinhibit

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NS5806
Cat. No.:
HY-108588
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