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Cat. No.: HY-P5786

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Heteropodatoxin-1

(Synonyms: HpTx1)

Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8.

For research use only. We do not sell to patients.

Formula: C₁₆₈H₂₃₈N₄₆O₅₁S₆
Molecular Weight:3910.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Heteropodatoxin-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8^[1].

All Sodium Channel Isoforms :

Chemical Information

Molecular Weight 3910.35
Formula C₁₆₈H₂₃₈N₄₆O₅₁S₆
Synonyms

HpTx1
Sequence

Asp-Cys-Gly-Thr-Ile-Trp-His-Tyr-Cys-Gly-Thr-Asp-Gln-Ser-Glu-Cys-Cys-Glu-Gly-Trp-Lys-Cys-Ser-Arg-Gln-Leu-Cys-Lys-Tyr-Val-Ile-Asp-Trp-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys22;Cys16-Cys27)
Sequence Shortening

DCGTIWHYCGTDQSECCEGWKCSRQLCKYVIDW-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys22;Cys16-Cys27)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xi Zhou, et al. Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels. Nat Commun. 2020 May 8;11(1):2293. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
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Heteropodatoxin-1

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Heteropodatoxin-1 Related Classifications

HY-P5786 Related Classifications