185855-91-8
Chemical Structure
CP-339818
- CAS No.: 185855-91-8
- Formula:C21H24N2
- Molecular Weight:304.43
IUPAC Name: (Z)-1-benzyl-N-pentylquinolin-4(1H)-imine
InChIKey: MMGAVKCAGQCFHS-XDOYNYLZSA-N
SMILES: CCCCC/N=C1C=CN(CC2=CC=CC=C2)C3=C/1C=CC=C3
Biological Activity: CP-339818 is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-). CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels[1][2][3].
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CP-339818 | CP-339818 is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-). CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels. | |||||||||||||||||||||
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- [1]. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation [Content Brief]
- [2]. Jacobson DA, et al. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588(Pt 18):3525-37. [Content Brief]
- [3]. Lee YT, et al. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. [Content Brief]
Keywords
