Kv4.2/KCND2 Antibody (YA6629)

Kv4.2/KCND2 Antibody (YA6629) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Kv4.2/KCND2.

Predicted band size: 70 kDa;

Q9Z0V2

16508 [NCBI]

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Function：Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (PubMed:10818150, PubMed:17122039, PubMed:18045912, PubMed:18187474, PubMed:20371829, PubMed:22815518). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites (PubMed:10818150, PubMed:17122039, PubMed:22815518). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:22815518). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (PubMed:18045912). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member (PubMed:10601491, PubMed:11909823, PubMed:23713033, PubMed:9734479). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:22311982, PubMed:9734479). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel (PubMed:11909823). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes (PubMed:11909823). Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (By similarity). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (PubMed:22311982). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (By similarity)

Subcellular Localization：Cell membrane,Cell projection, dendrite,Synapse,Perikaryon,Postsynaptic cell membrane,Cell projection, dendritic spine,Cell junction,Membrane, caveola,Cell membrane, sarcolemma

Expression：
Tissue_Specificity: Detected in hippocampus, thalamus, medial habenular nucleus, striatum, amygdala, brain cortex and cerebellum (PubMed:11040264, PubMed:17122039, PubMed:18187474, PubMed:20371829, PubMed:22612819). Detected in hippocampus CA1 and CA3 layer, in stratum oriens, stratum radiatum and stratum lacunosum-moleculare and in dentate gyrus (PubMed:16009497, PubMed:22098631). Detected in dorsal horn neurons; colocalizes with GRM5 (PubMed:18045912). C-terminally phosphorylated forms are detected in the stratum radiatum and in basilar dendrites in stratum oriens in hippocampus CA1 and on cell bodies in hippocampus CA3 layers, with lower levels in stratum lacunosum-moleculare (PubMed:11040264). In contrast, N-terminally phosphorylated forms are detected in stratum lacunosum moleculare in the hippocampus CA1 layer (PubMed:11040264). Both C-terminally and N-terminally phosphorylated forms are observed on cell bodies and neuronal processes in the amygdala (PubMed:11040264). C-terminally phosphorylated forms are detected in the dentate gyrus molecular layer, while N-terminally phosphorylated forms are detected in the hilus of the dentate gyrus (PubMed:11040264). Both N-terminally and C-terminally phosphorylated forms are detected in the somatosensory cortex (PubMed:11040264). C-terminally phosphorylated forms are detected in the cerebellum granular layers (PubMed:11040264). Detected in heart ventricle myocytes (at protein level) (PubMed:11909823, PubMed:16293790, PubMed:23713033, PubMed:9734479). Detected in brain and heart (PubMed:16293790)

Subunit：Homotetramer or heterotetramer with KCND3 or KCND1 (PubMed:11909823, PubMed:19713751, PubMed:20943905, PubMed:9734479)

KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_HUMAN antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; KCD2 antibody; KCND 2 antibody; KCND2 antibody; KCND2_HUMAN antibody; KIAA1044 antibody; MGC119702 antibody; MGC119703 antibody; Potassium voltage gated channel Shal related subfamily member 2 antibody; Potassium voltage-gated channel subfamily D member 2 antibody; RK 5 antibody; RK5 antibody; Voltage gated potassium channel Kv4.2 antibody; Voltage gated potassium channel subunit Kv4.2 antibody; Voltage sensitive potassium channel antibody; Voltage-gated potassium channel subunit Kv4.2 antibody;