Kcnd2 - potassium voltage-gated channel, Shal-related family, member 2 Gene

Also Known as Kv4.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16508

Summary

Enables A-type (transient outward) Potassium Channel activity and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including locomotor rhythm; neuronal action potential; and potassium ion transmembrane transport. Acts upstream of or within action potential. Located in several cellular components, including GABA-ergic synapse; dendritic spine; and postsynaptic membrane. Is integral component of postsynaptic membrane. Part of voltage-gated Potassium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including heart; hindlimb digit; metanephros; nervous system; and sensory organ. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnd2 Products (1)

mRNA Protein Name
NM_019697.4 NP_062671.1 potassium voltage-gated channel subfamily D member 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables A-type (transient outward) potassium channel activity IDA
IDA: Inferred from direct assay
9734479 MGI
enables A-type (transient outward) potassium channel activity IMP
IMP: Inferred from mutant phenotype
18045912 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15662035 MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
17582333 MGI
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
17582333 MGI
Biological Process GO Annotation Evidence References Source
involved in locomotor rhythm IMP
IMP: Inferred from mutant phenotype
22815518 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
20573902 MGI
involved in neuronal action potential IMP
IMP: Inferred from mutant phenotype
22815518 MGI
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
9734479 MGI
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
18045912 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
18045912 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
17122053 MGI
located in dendrite IDA
IDA: Inferred from direct assay
11040264 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
21943606 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17122053 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17582333 MGI
located in membrane IDA
IDA: Inferred from direct assay
18603586 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
11040264 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9734479 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
17122053 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
17122053 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
19713751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily D member 2

  • voltage-gated potassium channel subunit Kv4.2

Kcnd2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86936 Kv4.2/KCND2 Antibody (YA6629) IHC-F, IHC-P, WB Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07113 KCND2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21609 Kcnd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28127 Kcnd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnd2 NCBI NCBI:3751