CP 339818 hydrochloride
Based on 1 Customer Validation
CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 478341-55-8
- Formula: C21H25ClN2
- Molecular Weight:340.89
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Kv1.3 200 nM (IC50) |
Kv1.4 |
CP 339818 hydrochloride suppresses human T cell activation, suggesting that blockade of Kv1.3 alone is sufficient to inhibit this process[1].
CP 339818 (5 μM) hydrochloride effectively block the remaining outward potassium current in Kv2.1⁻/⁻ β cells, and does not significantly enhance glucose-stimulated insulin secretion (GSIS)[2].
CP 339818 (0-100 μM) hydrochloride's inhibitory effect on HCN1 and HCN4 in low-concentration of Cl- internal solution is weakened with IC50 of 26.2 and > 100 μM, , and this blocking effect is also voltage-dependent (the higher the voltage, the stronger the blocking effect)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 478341-55-8
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Appearance Solid
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Molecular Weight 340.89
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Formula C21H25ClN2
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Color White to off-white
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SMILES
CCCCC/N=C1C=CN(CC2=CC=CC=C2)C3=C\1C=CC=C3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (146.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. A Nguyen, et al. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec;50(6):1672-9. [Content Brief]
[2]. Jacobson DA, et al. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588(Pt 18):3525-37. [Content Brief]
[3]. Lee YT, et al. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9335 mL | 14.6675 mL | 29.3350 mL | 73.3374 mL |
| 5 mM | 0.5867 mL | 2.9335 mL | 5.8670 mL | 14.6675 mL | |
| 10 mM | 0.2933 mL | 1.4667 mL | 2.9335 mL | 7.3337 mL | |
| 15 mM | 0.1956 mL | 0.9778 mL | 1.9557 mL | 4.8892 mL | |
| 20 mM | 0.1467 mL | 0.7334 mL | 1.4667 mL | 3.6669 mL | |
| 25 mM | 0.1173 mL | 0.5867 mL | 1.1734 mL | 2.9335 mL | |
| 30 mM | 0.0978 mL | 0.4889 mL | 0.9778 mL | 2.4446 mL | |
| 40 mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.8334 mL | |
| 50 mM | 0.0587 mL | 0.2933 mL | 0.5867 mL | 1.4667 mL | |
| 60 mM | 0.0489 mL | 0.2445 mL | 0.4889 mL | 1.2223 mL | |
| 80 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9167 mL | |
| 100 mM | 0.0293 mL | 0.1467 mL | 0.2933 mL | 0.7334 mL |
CP 339818 hydrochloride Related Classifications
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