2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. BmP02

BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells.

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BmP02 Chemical Structure

BmP02 Chemical Structure

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BmP02 Related Antibodies

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Description

BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells[1][2].

IC50 & Target

Kv1.3, Kv4.2[1]
Molecular Weight

2949.35

Formula

C115H182N36O41S7
Sequence

Val-Gly-Cys-Glu-Glu-Cys-Pro-Met-His-Cys-Lys-Gly-Lys-Asn-Ala-Lys-Pro-Thr-Cys-Asp-Asp-Gly-Val-Cys-Asn-Cys-Asn-Val (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
Sequence Shortening

VGCEECPMHCKGKNAKPTCDDGVCNCNV (Disulfide bonds：Cys3-Cys19, Cys6-Cys24, Cys10-Cys26)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BmP02 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BmP02BmP 02BmP-02Potassium ChannelKcsAChinese scorpionButhus martensi KarschHEK293T cellstransient outward potassium currentsItoventricular muscle cellsInhibitorinhibitorinhibit

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