741738-59-0
Chemical Structure
Stromatoxin 1
- CAS. Nr.: 741738-59-0
- Formula:C156H237N49O48S7
- Molecular Weight:3791.31
SMILES: O=C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(NC3)=O)=O)=O)=O)NC4=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CC5=CC=CC=C5)C(NCC(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H]7CC8=CC=C(C=C8)O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@H]4CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC9=CNC%10=CC=CC=C9%10)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N)=O)=O)=O)=O)=O)=O)=O)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Stromatoxin 1 | Stromatoxin 1 is an inhibitor of Potassium Channel, a peptide which can be isolated from tarantulas. Stromatoxin 1 selectively inhibits K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3 channels. K(V)2.1 and K(V)2.2, but not K(V)4.2, channel subunits play a key role in opposing both myogenic and neurogenic urinary bladder smooth muscle (UBSM) contractions in rats. | |||||||||||||||||||||
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