741738-59-0
Chemical Structure
Stromatoxin 1
- CAS 番号: 741738-59-0
- Formula:C156H237N49O48S7
- Molecular Weight:3791.31
SMILES: O=C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(NC3)=O)=O)=O)=O)NC4=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CC5=CC=CC=C5)C(NCC(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H]7CC8=CC=C(C=C8)O)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@H]4CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC9=CNC%10=CC=CC=C9%10)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N)=O)=O)=O)=O)=O)=O)=O)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: Stromatoxin 1 is a peptide potassium channel inhibitor that can be isolated from tarantulas. Stromatoxin 1 selectively inhibits Kv2.1/2.2, Kv4.2, and Kv2.1/6.3 or Kv2.1/9.3 channels, reduces KV and fast-inactivating IA currents, and inhibits peak and persistent K+ currents. Stromatoxin 1 enhances cell excitability through electrophysiological changes such as shortening of afterhyperpolarization and the refractory period, thereby increasing intracellular calcium, promoting glucose-stimulated insulin secretion from rodent β cells/islets, and enhancing contraction of human detrusor smooth muscle. Stromatoxin 1 improves conduction fidelity in uninjured sensory neurons. Stromatoxin 1 can be used in research related to neuropathic pain[1][2][3][4][5][6][7].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Stromatoxin 1 | Stromatoxin 1 is a peptide potassium channel inhibitor that can be isolated from tarantulas. Stromatoxin 1 selectively inhibits Kv2.1/2.2, Kv4.2, and Kv2.1/6.3 or Kv2.1/9.3 channels, reduces KV and fast-inactivating IA currents, and inhibits peak and persistent K+ currents. Stromatoxin 1 enhances cell excitability through electrophysiological changes such as shortening of afterhyperpolarization and the refractory period, thereby increasing intracellular calcium, promoting glucose-stimulated insulin secretion from rodent β cells/islets, and enhancing contraction of human detrusor smooth muscle. Stromatoxin 1 improves conduction fidelity in uninjured sensory neurons. Stromatoxin 1 can be used in research related to neuropathic pain. | |||||||||||||||||||||
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References
- [1]. Idres S, et al. Contribution of BKCa channels to vascular tone regulation by PDE3 and PDE4 is lost in heart failure. Cardiovascular research. 2019 Jan 01;115(1):130-144.
- [2]. Kusunoki M, et al. Propofol inhibits stromatoxin-1-sensitive voltage-dependent K channels in pancreatic β-cells and enhances insulin secretion. PeerJ. 2019;7:e8157.
- [3]. Tsantoulas C, et al. Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input. Experimental neurology. 2014 Jan;251:115-26.
- [4]. Braun M, et al. Voltage-gated ion channels in human pancreatic β-cells: electrophysiological characterization and role in insulin secretion. Diabetes. 2008 Jun 1;57(6):1618-28.
- [5]. Yamada A, et al. Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles. Journal of neurophysiology. 2025 Nov 01;134(5):1762-1773.
- [6]. Hristov KL, et al. Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle. American journal of physiology. Cell physiology. 2012 Jun 01;302(11):C1599-608.
- [7]. Hristov KL, et al. KV2.1 and electrically silent KV channel subunits control excitability and contractility of guinea pig detrusor smooth muscle. American journal of physiology. Cell physiology. 2012 Jan 15;302(2):C360-72.
