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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
Ketohexokinases
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "Ketohexokinases" in MCE Product Catalog:
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Ketohexokinases is a transglutaminase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
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1 Cited Publications
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KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity .
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1 Cited Publications
Cat. No.: HY-12841
CAS No.: 1303469-70-6
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KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity .
Cat. No.: HY-U00461
CAS No.: 2102501-84-6
Synonyms: Ketohexokinase inhibitor 1
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PF-06835919 (Ketohexokinase inhibitor 1) is a ketohexokinase (KHK) inhibitor, with IC50 values of 0.028 μM and 0.17 μM against human KHK-C and KHK-A, respectively, and an IC50 value of 0.21 μM against rat KHK. PF-06835919 blocks fructose (HY-N0395) phosphorylation and fructose metabolism. PF-06835919 can be used for research on metabolic dysfunction-associated steatotic liver disease, type 2 diabetes, hereditary fructose intolerance, and related conditions .
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KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
Synonyms: KHK-IN-3
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation .
Cat. No.: HY-161993
CAS No.: 3043939-18-7
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BI-9787 is a zwitterionic inhibitior for ketohexokinase, with an IC50 of 12 and 12.8 nM for hKHK-A and hKHK-C. BI-9787 exhibits good metabolic stability in rat hepatocyte and good pharmacokinetic characteristics in rats .
Cat. No.: HY-177664
CAS No.: 2894810-55-8
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Senvesiran, a siRNA, is a ketohexokinase synthesis reducer.
Cat. No.: HY-177664A
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Senvesiran sodium, a siRNA, is a ketohexokinase synthesis reducer.
Cat. No.: HY-149605
CAS No.: 3034829-40-5
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KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research .
Cat. No.: HY-172610
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KHK-IN-7 (compound 2) is a ketohexokinase (KHK) inhibitor. KHK-IN-7 can be used for study of metabolic disorders .
Cat. No.: HY-161993A
CAS No.: 3043939-19-8
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(αR)-BI-9787 is the epimer of BI-9787 (HY-161993). BI-9787 is a zwitterionic inhibitior for ketohexokinase.
Cat. No.: HY-103478R
CAS No.: 2135304-43-5
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KHK-IN-2 (Standard) is the analytical standard of KHK-IN-2 (HY-103478). This product is intended for research and analytical applications. KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
Cat. No.: HY-208737
CAS No.: 3108075-72-2
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KHK-IN-8 is a selective KHK inhibitor, with an IC50 of 13.0 nM against hKHK-C and an IC50 of 22.7 nM against hKHK-A. KHK-IN-8 is applicable to research on non-alcoholic steatohepatitis, type 2 diabetes and obesity .
Cat. No.: HY-180921
CAS No.: 2845278-33-1
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GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC50s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
