1303470-48-5
Chemical Structure
KHK-IN-1 hydrochloride
- CAS No.: 1303470-48-5
- Formula:C21H27ClN8S
- Molecular Weight:459.01
IUPAC Name: N8-(cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine hydrochloride
InChIKey: VKIBPWKARAEIHN-UHFFFAOYSA-N
SMILES: [H]Cl.CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5
Biological Activity: KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KHK-IN-1 hydrochloride | 98.03% | KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity. | ||||||||||||||||||||
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Keywords
