1303469-70-6
1303469-70-6
Chemical Structure
KHK-IN-1
- CAS No.: 1303469-70-6
- Formula:C21H26N8S
- Molecular Weight:422.55
IUPAC Name: N8-(cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
InChIKey: HFLMLZKGLUEWBU-UHFFFAOYSA-N
SMILES: CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5
Biological Activity: KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KHK-IN-1 | 99.00% | KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity. | ||||||||||||||||||||
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References
Keywords
