44 Results for "

LL37

" in MedChemExpress (MCE) Product Catalog:
Products (44)

44 Results for "LL37" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-P1222
CAS No.: 154947-66-7
Target:  

Bacterial

Research Areas:  

Infection

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing .
loading...
    loading...
6
6 Publications Verification
Cat. No.: HY-P1222A
Target:  

Bacterial

Research Areas:  

Infection

LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing .
loading...
    loading...
6
6 Publications Verification
Cat. No.: HY-P1222B
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-32350
CAS No.: 60133-18-8
Synonyms: 1α,25-Dihydroxy Vitamin D2
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P4744
CAS No.: 597562-32-8
Research Areas:  

Infection Cancer

LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P4744A
Research Areas:  

Infection Cancer

LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P4855
CAS No.: 376364-36-2
Target:  

Bacterial TNF Receptor

Research Areas:  

Infection Inflammation/Immunology

CRAMP (mouse) is an antibacterial peptide and a functional homolog of LL-37 . CRAMP (mouse) exhibits potent antibacterial activity against Gram-negative bacteria . The complex formed by CRAMP (mouse) and CpG can activate macrophages to secrete TNF-α . CRAMP (mouse) plays a key role in wound healing, immune regulation and maintenance of intestinal homeostasis .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N9366
CAS No.: 508-24-7
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM .
loading...
    loading...
Cat. No.: HY-P1513A
Target:  

Bacterial

Research Areas:  

Infection

LL-37 scrambled peptide acetate is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide acetate can be used as a negative control of LL-37 peptide studies.
loading...
    loading...
Cat. No.: HY-P1884
Target:  

Bacterial

Research Areas:  

Infection

LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
loading...
    loading...
Cat. No.: HY-P5391
CAS No.: 717919-61-4
Target:  

BCRP

Research Areas:  

Cancer

LL-37 (17-32) is an ABCG2 inhibitor. LL-37 (17-32) binds to ABCG2, inhibits its transport activity in a non-competitive manner, and downregulates ABCG2 protein expression via lysosomal degradation. LL-37 (17-32) increases the accumulation of Mitoxantrone (HY-13502) in cancer cells overexpressing ABCG2, thereby reversing mitoxantrone resistance. LL-37 (17-32) can be used in the research of multidrug-resistant cancers .
loading...
    loading...
Cat. No.: HY-P4128
CAS No.: 1072128-56-3
Target:  

Bacterial Antibiotic

Research Areas:  

Others

LL-37 SKE is an active fragment of LL-37 .
loading...
    loading...
Cat. No.: HY-P10257
CAS No.: 1218951-51-9
Target:  

Bacterial

Research Areas:  

Infection

KR-12 (human) is an active segment of LL-37 (HY-P4744). KR-12 (human) exhibits antimicrobial activity against gram-negative bacteria. KR-12 (human) inhibits E. coli K-12 with a MIC of 66 μM. KR-12 human can be used for the research of infection, such as E. coli infection .
loading...
    loading...
Cat. No.: HY-P4836A
Target:  

Parasite

Research Areas:  

Infection

LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
loading...
    loading...
Cat. No.: HY-P1513
Target:  

Bacterial

Research Areas:  

Infection

LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide can be used as a negative control of LL-37 peptide studies.
loading...
    loading...
Cat. No.: HY-A0248B
CAS No.: 34503-87-2
Target:  

Antibiotic Bacterial

Research Areas:  

Infection Inflammation/Immunology

Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis .
loading...
    loading...
Cat. No.: HY-P5057A
Research Areas:  

Infection

5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy .
loading...
    loading...
Cat. No.: HY-P4741
CAS No.: 2022972-70-7
Target:  

Peptides

Research Areas:  

Others

LL-37 (37-1) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
loading...
    loading...
Cat. No.: HY-P4747
CAS No.: 913736-92-2
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

LL-37 GKE is an active domain of LL-37. LL-37 GKE has antibacterial activity and has potential applications in antibiotics .
loading...
    loading...
Cat. No.: HY-P4836
CAS No.: 717919-68-1
Target:  

Parasite

Research Areas:  

Infection

LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
loading...
    loading...