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  6. Tumulosic acid

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM.

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Tumulosic acid Chemical Structure

Tumulosic acid Chemical Structure

CAS No. : 508-24-7

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Tumulosic acid Related Antibodies

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Description

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

In Vitro

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes[1].
Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tumulosic acid Related Antibodies

Western Blot Analysis[1]

Cell Line: Normal human epidermal keratinocytes (NHEKs)
Concentration: 1 μM and 10 μM
Incubation Time: 23 h in the presence of 10 μM cycloheximide
Result: Decreased LL-37 production in epidermal keratinocytes.
Molecular Weight

486.73

Formula

C31H50O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@](C(CC[C@](C(C)1C)([H])[C@@]2(CC[C@@H]1O)C)=C2CC3)(C[C@H]4O)[C@]3([C@@]4([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tumulosic acid508-24-7OtherstriterpenoidKLK5proteaseproteolyticLL-37keratinocytesInhibitorinhibitorinhibit

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