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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
LRH-1
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "LRH-1" in MCE Product Catalog:
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ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] .
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3 Cited Publications
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine
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2 Cited Publications
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RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively [1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .
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1 Cited Publications
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RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease [1] .
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1 Cited Publications
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7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC50 of 3.1 μM [1].
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LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease [1].
Cat. No.: HY-134462
CAS No.: 1276664-14-2
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RJW103 is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors [1] .
Cat. No.: HY-118054
CAS No.: 1185410-60-9
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LRH-1 Inhibitor-3 is a small molecule that inhibits LRH-1 transcriptional activity, thereby decreasing the expression of target genes associated with cell growth and proliferation. LRH-1 Inhibitor-3 has shown potential in reducing cancer cell proliferation in human pancreatic, colon, and breast adenocarcinoma cell lines. LRH-1 Inhibitor-3 serves as a molecular probe for investigating the role of LRH-1 in various malignancies.
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ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer [1].
Cat. No.: HY-147105A
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(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 has anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and reduces the inflammatory cytokines IL-1b and TNFa [1].
Cat. No.: HY-173340
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LRH-1 agonist-1 (compound 74) is an agonist of LRH-1 with IC50 value of 47 μM [1].
Cat. No.: HY-134462A
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RJW103 TFA is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 TFA activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 TFA can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors [1] .
Cat. No.: HY-128453
CAS No.: 1185486-16-1
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LRH-1 antagonist-1 (Compound 3d2) is a LRH-1 antagonist with a Kd of 1.8 μM. LRH-1 antagonist-1 inhibits the transcriptional activity of LRH-1 and reduces the expression of G0S2. LRH-1 antagonist-1 inhibits the proliferation of LRH-1-positive cancer cells. LRH-1 antagonist-1 can be used for research on pancreatic cancer, colon cancer and breast cancer [1].
Cat. No.: HY-128453A
CAS No.: 2932459-63-5
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LRH-1 antagonist-1 (Compound 3d2) dihydrochloride is a LRH-1 antagonist with a Kd of 1.8 μM. LRH-1 antagonist-1 dihydrochloride inhibits the transcriptional activity of LRH-1 and reduces the expression of G0S2. LRH-1 antagonist-1 dihydrochloride inhibits the proliferation of LRH-1-positive cancer cells. LRH-1 antagonist-1 dihydrochloride can be used for research on pancreatic cancer, colon cancer and breast cancer [1].
Cat. No.: HY-P4628
CAS No.: 2022956-41-6
Synonyms: LRH-1 peptide
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Cat. No.: HY-131445A
Purity: 99.91%
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SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability [1] .
Cat. No.: HY-155168
CAS No.: 1276664-61-9
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Iso-RJW100 (compound 24-endo) is a dual-liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) agonist with pEC50 of 6.4 and 7.2, respectively [1].
Cat. No.: HY-402601
Desethyl-SID 7969543 is an isoquinolinone analog of SID 7969543 (HY-107404) and a selective SF-1 (NR5A1) inhibitor. Desethyl-SID 7969543 shows no activity against RORA, VP16 and LRH-1, and exhibits no cytotoxicity at concentrations close to its SF-1 IC50 value [1] .
Cat. No.: HY-RS09554
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NR5A2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR5A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09909
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P2RX5 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RX5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
