1276664-14-2
Chemical Structure
RJW103
- CAS No.: 1276664-14-2
- Formula:C28H35N
- Molecular Weight:385.58
IUPAC Name: (3aR,6aS)-5-hexyl-2-methyl-6-phenyl-6a-(1-phenylvinyl)-1,2,3,3a,4,6a-hexahydrocyclopenta[c]pyrrole
InChIKey: RVIUUYICERBOIG-XCZPVHLTSA-N
SMILES: C=C([C@]1(C(C2=CC=CC=C2)=C(CCCCCC)C3)[C@]3([H])CN(C)C1)C4=CC=CC=C4
Biological Activity: RJW103 is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RJW103 | 98.71% | RJW103 is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors. | ||||||||||||||||||||
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- [1]. Whitby RJ, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011;54(7):2266-2281. [Content Brief]
- [2]. Wu T, et al. Liver receptor homolog-1: structures, related diseases, and drug discovery. Acta Pharmacol Sin. 2024;45(8):1571-1581. [Content Brief]
Keywords
