Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
Licochalcone A
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "Licochalcone A" in MCE Product Catalog:
19
19 Publications Verification
Cat. No.: HY-N0372
CAS No.: 58749-22-7
Category:
Flavonoids Chalcones Leguminosae Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer
Target:
12
12 Cited Publications
Cat. No.: HY-N0373
CAS No.: 58749-23-8
5
5 Cited Publications
Cat. No.: HY-N4187
CAS No.: 144506-15-0
5
5 Cited Publications
Cat. No.: HY-N0374
CAS No.: 144506-14-9
Category:
Flavonoids Chalcones Leguminosae Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch.
Target:
4
4 Cited Publications
Cat. No.: HY-N4182
CAS No.: 864232-34-8
Cat. No.: HY-N0372R
CAS No.: 58749-22-7
Target:
Cat. No.: HY-N0373R
CAS No.: 58749-23-8
Cat. No.: HY-174324
Target:
Research Areas:
VEGFR-2/P-gp-IN-1, a Licochalcone A (HY-N0372) derivative, is an orally active VEGFR-2 (IC50 = 0.885 μM) and P-gp inhibitor. VEGFR-2/P-gp-IN-1 achieves anti-tumor proliferation and overcomes chemotherapy resistance by synchronously inhibiting VEGFR-2 kinase activity and P-gp drug efflux pump function. VEGFR-2/P-gp-IN-1 inhibits phosphorylation of VEGFR-2 and downstream PI3K/AKT signaling pathway proteins, induces apoptosis, blocks cells in the S phase, and inhibits invasive migration. VEGFR-2/P-gp-IN-1 exerts potent in vivo anti-tumor effects in the HeLa/DDP cell xenograft tumor model. VEGFR-2/P-gp-IN-1 is used in cervical cancer research.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
