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Michael addition

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35

Inhibitors & Agonists

27

Biochemical Assay Reagents

1

Peptides

2

Natural
Products

1

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-166648
    DSPE-PEG2000-Maleimide sodium (purity>99%)
    1 Publications Verification

    		 Liposome Cancer
    DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery .
    DSPE-PEG2000-Maleimide sodium (purity>99%)
  • HY-Y0232
    Meldrum's acid

    2,2-Dimethyl-1,3-dioxane-4,6-dione

    		 Biochemical Assay Reagents Others
    Meldrum's acid (2,2-Dimethyl-1,3-dioxane-4,6-dione) is a nucleophilic reagent. Meldrum's acid participates in Michael addition reactions. Meldrum's acid can be used in asymmetric organocatalysis .
    Meldrum's acid
  • HY-I0259
    8-Amino-2-naphthol

    		Fluorescent Dye Others
    8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol undergoes excited-state proton transfer (ESPT) to form a zwitterion under acidic conditions, where the photoacidity of its hydroxyl group is regulated by the protonation state of the amino group, enabling pH to act as an on/off switch for photoacidity. 8-Amino-2-naphthol is also utilized as chiral organocatalyst .
    8-Amino-2-naphthol
  • HY-P4566
    H-Pro-Val-OH

    Pro-Val

    		 Dipeptidyl Peptidase Others
    H-Pro-Val-OH is a deprotonation dipeptide containing proline, which can catalyze the Michael addition reaction of acetone to trans-β-nitrostyrene. H-Pro Val OH can also serve as a substrate for fibroblast enzymes and prolinase, and has potential applications in biochemical analysis .
    H-Pro-Val-OH
  • HY-166648A
    DSPE-PEG-Maleimide ammonium (MW 2000)
    1 Publications Verification

    		 Liposome Others
    DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .
    DSPE-PEG-Maleimide ammonium (MW 2000)
  • HY-16261A
    MC-DOXHZN

    (E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone

    		 ADC Payload Topoisomerase Cancer
    MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN can be used to synthesize ADC .
    MC-DOXHZN
  • HY-W190755
    Mal-PEG4-mal

    		Biochemical Assay Reagents Others
    Mal-PEG4-Mal is a PEG derivative with maleimide groups at both ends. Maleimide is a functional group that can undergo Michael addition reactions with sulfhydryl groups (–SH) and can be used for bioconjugation .
    Mal-PEG4-mal
  • HY-W010354
    2,2-Diethoxyethanol

    		Drug Intermediate Infection
    2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection .
    2,2-Diethoxyethanol
  • HY-185048
    PCB-OAA

    		Drug Intermediate Neurological Disease
    PCB-OAA is a biocompatible multivinyl polycarboxybetaine macromonomer and that exhibits anti-fouling activity. PCB-OAA can form a hydrogel in vitreous cavity and shows an appealing ability to prevent significantly inflammatory response, fibrosis and complications such as raised intraocular pressure, and cataract formation. PCB-OAA can be used for the research of vitreous substitution .
    PCB-OAA
  • HY-150587
    Anti-inflammatory agent 31

    		ERK NF-κB Inflammation/Immunology
    Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver .
    Anti-inflammatory agent 31
  • HY-W190746
    Mal-PEG1-Mal

    		Biochemical Assay Reagents Others
    Mal-PEG1-Mal is a PEG derivative with maleimide groups at both ends. Maleimide is a functional group that can undergo Michael addition reactions with sulfhydryl groups (–SH) and can be used for bioconjugation .
    Mal-PEG1-Mal
  • HY-W697750
    trans-2-Methyl-2-butenal

    Tiglaldehyde

    		 Biochemical Assay Reagents Cancer
    trans-2-Methyl-2-butenal (Tiglaldehyde) is an adduct former that can be found in cigarette smoke, and very weakly inhibits growth of cancer cells and normal mouse cells. trans-2-Methyl-2-butenal forms adducts with glutathione (GSH) via Michael addition.trans-2-Methyl-2-butenal is an α,β-unsaturated carbonyl compound .
    trans-2-Methyl-2-butenal
  • HY-174941
    Mal-PEG18-acid

    		Biochemical Assay Reagents Others
    Mal-PEG18-acid is a PEG derivative modified with maleimide groups. Maleimide is a functional group that can undergo Michael addition reaction with sulfhydryl (–SH) groups and can be used for bioconjugation.
    Mal-PEG18-acid
  • HY-W1052492
    DPPE-PEG2000-Mal

    		Biochemical Assay Reagents Others
    DPPE-PEG2000-Mal is a conjugate composed of DPPE, PEG chains, and maleimide (Mal). The maleimide group in DPPE-PEG2000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DPPE-PEG2000-Mal
  • HY-W1052227A
    DMPE-PEG3400-Mal

    		Biochemical Assay Reagents Others
    DMPE-PEG3400-Mal is a conjugate composed of DMPE, PEG chains, and maleimide (Mal). The maleimide group in DMPE-PEG3400-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DMPE-PEG3400-Mal
  • HY-183126A
    DSG-PEG2000-Mal

    		Biochemical Assay Reagents Others
    DSG-PEG2000-Mal is a conjugate composed of DSG, PEG chains, and maleimide (Mal). The maleimide group in DSG-PEG2000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DSG-PEG2000-Mal
  • HY-183126B
    DSG-PEG3400-Mal

    		Biochemical Assay Reagents Others
    DSG-PEG3400-Mal is a conjugate composed of DSG, PEG chains, and maleimide (Mal). The maleimide group in DSG-PEG3400-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DSG-PEG3400-Mal
  • HY-183126D
    DSG-PEG10000-Mal

    		Biochemical Assay Reagents Others
    DSG-PEG10000-Mal is a conjugate composed of DSG, PEG chains, and maleimide (Mal). The maleimide group in DSG-PEG10000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DSG-PEG10000-Mal
  • HY-W1052227C
    DMPE-PEG1000-Mal

    		Biochemical Assay Reagents Others
    DMPE-PEG1000-Mal is a conjugate composed of DMPE, PEG chains, and maleimide (Mal). The maleimide group in DMPE-PEG1000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DMPE-PEG1000-Mal
  • HY-W1052227B
    DMPE-PEG5000-Mal

    		Biochemical Assay Reagents Others
    DMPE-PEG5000-Mal is a conjugate composed of DMPE, PEG chains, and maleimide (Mal). The maleimide group in DMPE-PEG5000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DMPE-PEG5000-Mal
  • HY-W1052492C
    DPPE-PEG1000-Mal

    		Biochemical Assay Reagents Others
    DPPE-PEG1000-Mal is a conjugate composed of DPPE, PEG chains, and maleimide (Mal). The maleimide group in DPPE-PEG1000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DPPE-PEG1000-Mal
  • HY-W1052492B
    DPPE-PEG5000-Mal

    		Biochemical Assay Reagents Others
    DPPE-PEG5000-Mal is a conjugate composed of DPPE, PEG chains, and maleimide (Mal). The maleimide group in DPPE-PEG5000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DPPE-PEG5000-Mal
  • HY-W1052227D
    DMPE-PEG10000-Mal

    		Biochemical Assay Reagents Others
    DMPE-PEG10000-Mal is a conjugate composed of DMPE, PEG chains, and maleimide (Mal). The maleimide group in DMPE-PEG10000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DMPE-PEG10000-Mal
  • HY-W1052492A
    DPPE-PEG3400-Mal

    		Biochemical Assay Reagents Others
    DPPE-PEG3400-Mal is a conjugate composed of DPPE, PEG chains, and maleimide (Mal). The maleimide group in DPPE-PEG3400-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DPPE-PEG3400-Mal
  • HY-W1052492D
    DPPE-PEG10000-Mal

    		Biochemical Assay Reagents Others
    DPPE-PEG10000-Mal is a conjugate composed of DPPE, PEG chains, and maleimide (Mal). The maleimide group in DPPE-PEG10000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DPPE-PEG10000-Mal
  • HY-183126C
    DSG-PEG5000-Mal

    		Biochemical Assay Reagents Others
    DSG-PEG5000-Mal is a conjugate composed of DSG, PEG chains, and maleimide (Mal). The maleimide group in DSG-PEG5000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DSG-PEG5000-Mal
  • HY-W1052227
    DMPE-PEG2000-Mal

    		Biochemical Assay Reagents Others
    DMPE-PEG2000-Mal is a conjugate composed of DMPE, PEG chains, and maleimide (Mal). The maleimide group in DMPE-PEG2000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DMPE-PEG2000-Mal
  • HY-183126
    DSG-PEG1000-Mal

    		Biochemical Assay Reagents Others
    DSG-PEG1000-Mal is a conjugate composed of DSG, PEG chains, and maleimide (Mal). The maleimide group in DSG-PEG1000-Mal can undergo a specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), enabling targeted modification of liposomes/nanoparticles.
    DSG-PEG1000-Mal
  • HY-186171
    Mal-(1R,2S,3R,4S)-himic acid-alkyne

    		Biochemical Assay Reagents Others
    Mal-(1R,2S,3R,4S)-himic acid-alkyne is a trifunctional click chemistry scaffold containing complementary functionalities for copper catalyzed azide-alkyne (CuAAC), thiol-Michael addition, and inverse electron demand Diels-Alder (iEDDA) click reactions .
    Mal-(1R,2S,3R,4S)-himic acid-alkyne
  • HY-171337B
    C18-PEG5000-Mal

    		Biochemical Assay Reagents Others
    C18-PEG5000-Mal is a conjugate composed of a octadecyl (C18 aliphatic chain), a PEG chain, and maleimide (Mal). C18-PEG5000-Mal combines the membrane compatibility of lipids with the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), making it suitable for research in biomaterial construction and drug delivery.
    C18-PEG5000-Mal
  • HY-183135
    C16-PEG2000-Mal

    		Biochemical Assay Reagents Others
    C16-PEG2000-Mal is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and maleimide (Mal). C16-PEG2000-Mal combines the membrane compatibility of lipids with the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), making it suitable for research in biomaterial construction and drug delivery.
    C16-PEG2000-Mal
  • HY-171337
    C18-PEG2000-Mal

    		Biochemical Assay Reagents Others
    C18-PEG2000-Mal is a conjugate composed of a octadecyl (C18 aliphatic chain), a PEG chain, and maleimide (Mal). C18-PEG2000-Mal combines the membrane compatibility of lipids with the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), making it suitable for research in biomaterial construction and drug delivery.
    C18-PEG2000-Mal
  • HY-183135A
    C16-PEG3400-Mal

    		Biochemical Assay Reagents Others
    C16-PEG3400-Mal is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and maleimide (Mal). C16-PEG3400-Mal combines the membrane compatibility of lipids with the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), making it suitable for research in biomaterial construction and drug delivery.
    C16-PEG3400-Mal
  • HY-183135B
    C16-PEG5000-Mal

    		Biochemical Assay Reagents Others
    C16-PEG5000-Mal is a conjugate composed of a hexadecyl (C16 aliphatic chain), a PEG chain, and maleimide (Mal). C16-PEG5000-Mal combines the membrane compatibility of lipids with the specific Michael addition reaction with thiol-containing (-SH) biomolecules (such as peptides, antibodies, and aptamers), making it suitable for research in biomaterial construction and drug delivery.
    C16-PEG5000-Mal
  • HY-179293
    SARS-CoV-2 PLpro-IN-3

    		SARS-CoV Virus Protease Infection
    SARS-CoV-2 PLpro-IN-3 (Compound 15) is a covalent inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 25 nM. SARS-CoV-2 PLpro-IN-3 has similar inhibitory activity against SARS-CoV PLpro (IC50 = 59 nM), but shows no inhibitory effect on human ubiquitin-specific protease 7 (USP7). The EC50 of SARS-CoV-2 PLpro-IN-3 in inhibiting SARS-CoV-2 replication in cells is 96 nM, significantly reducing the viral titer and viral RNA levels. SARS-CoV-2 PLpro-IN-3 can be used for studying SARS-CoV-2 drug resistance mutations .
    SARS-CoV-2 PLpro-IN-3

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