PCB-OAA
Based on 1 Customer Validation
PCB-OAA is a biocompatible multivinyl polycarboxybetaine macromonomer and that exhibits anti-fouling activity. PCB-OAA can form a hydrogel in vitreous cavity and shows an appealing ability to prevent significantly inflammatory response, fibrosis and complications such as raised intraocular pressure, and cataract formation. PCB-OAA can be used for the research of vitreous substitution.
For research use only. We do not sell to patients.
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PCB-OAA (7-10 %; 90 min) hydrogels have excellent antifouling capacity against nonspecific protein adsorption[1].
PCB-OAA (7-10 %; 24-48 h) hydrogels resist L929 cell attachment, demonstrating excellent antifouling capacity[1].
PCB-OAA (7-10 %; 24-72 h) hydrogels have excellent cytocompatibility with ARPE-19 cells, maintaining over 90% cell viability for 72 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human retinal epithelium ARPE-19 cells
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Concentration:7 %, 8.5 %, 10 %
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Incubation Time:24 h, 48 h, 72 h
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Result:Maintained above 90 % relative cell viability after 72 h of co-incubation.
PCB-OAA-7 hydrogel (7% solution mixed with 200 mM DTT at 10/1 volume ratio; s.c.; single dose) exhibits excellent in vivo biocompatibility and anti-fibrosis ability in mouse subcutaneous tissue[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 6 weeks old, 20 g)[1]
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Dosage:7% PCB-OAA solution mixed with 200 mM DTT at a 10/1 volume ratio, forming PCB-OAA-7 hydrogel
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Administration:Subcutaneously injection; single dose
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Result:Showed negligible inflammatory cells or deposited collagen around subcutaneous implantation sites throughout 28 days of observation.
Chemical Information
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Appearance Solid
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SMILES
CC(C(OCC(OC(C=C)=O)C[N+](C)(C)CC([O-])=O)=O)(C)CC(C(OCC(O)C[N+](C)(C)CC([O-])=O)=O)(C)CC.[m].[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PCB-OAA Related Classifications
HY-185048 Related Classifications
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