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  3. Drug Intermediate
  4. PCB-OAA

PCB-OAA is a biocompatible multivinyl polycarboxybetaine macromonomer and that exhibits anti-fouling activity. PCB-OAA can form a hydrogel in vitreous cavity and shows an appealing ability to prevent significantly inflammatory response, fibrosis and complications such as raised intraocular pressure, and cataract formation. PCB-OAA can be used for the research of vitreous substitution.

For research use only. We do not sell to patients.

PCB-OAA

PCB-OAA Chemical Structure

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Based on 1 publication(s) in Google Scholar

PCB-OAA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

PCB-OAA is a biocompatible multivinyl polycarboxybetaine macromonomer and that exhibits anti-fouling activity. PCB-OAA can form a hydrogel in vitreous cavity and shows an appealing ability to prevent significantly inflammatory response, fibrosis and complications such as raised intraocular pressure, and cataract formation. PCB-OAA can be used for the research of vitreous substitution[1].

In Vitro

PCB-OAA (7-10 %; 90 min) hydrogels have excellent antifouling capacity against nonspecific protein adsorption[1].
PCB-OAA (7-10 %; 24-48 h) hydrogels resist L929 cell attachment, demonstrating excellent antifouling capacity[1].
PCB-OAA (7-10 %; 24-72 h) hydrogels have excellent cytocompatibility with ARPE-19 cells, maintaining over 90% cell viability for 72 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PCB-OAA Related Antibodies

Cell Viability Assay[1]

Cell Line: human retinal epithelium ARPE-19 cells
Concentration: 7 %, 8.5 %, 10 %
Incubation Time: 24 h, 48 h, 72 h
Result: Maintained above 90 % relative cell viability after 72 h of co-incubation.
In Vivo

PCB-OAA-7 (7% solution mixed with 200 mM DTT at 10/1 volume ratio; intravitreally; single dose) hydrogel is stable in rabbit vitreous cavities for 6 months, maintains normal retinal function and intraocular pressure, and exhibits excellent biocompatibility without adverse ocular effects[1].
PCB-OAA-7 hydrogel (7% solution mixed with 200 mM DTT at 10/1 volume ratio; s.c.; single dose) exhibits excellent in vivo biocompatibility and anti-fibrosis ability in mouse subcutaneous tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 6 weeks old, 20 g)[1]
Dosage: 7% PCB-OAA solution mixed with 200 mM DTT at a 10/1 volume ratio, forming PCB-OAA-7 hydrogel
Administration: Subcutaneously injection; single dose
Result: Showed negligible inflammatory cells or deposited collagen around subcutaneous implantation sites throughout 28 days of observation.
Appearance

Solid

SMILES

CC(C(OCC(OC(C=C)=O)C[N+](C)(C)CC([O-])=O)=O)(C)CC(C(OCC(O)C[N+](C)(C)CC([O-])=O)=O)(C)CC.[m].[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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PCB-OAA Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCB-OAADrug IntermediateDrug Iintermediatefibrosiscataract formationhuman vitreous bodyMichael addition reactionraised intraocular pressureARPE-19 cellsL929 cellinflammatory responseInhibitorinhibitorinhibit

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