2 Results for "

Mogroside III-E

" in MedChemExpress (MCE) Product Catalog:
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2 Results for "Mogroside III-E" in MCE Product Catalog:

Mogroside III-E
Mogroside III-E
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Cat. No.: HY-N6928
CAS No.: 88901-37-5
Category:  

Triterpenes Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields

Target:  

Toll-like Receptor (TLR) ERK JNK p38 MAPK TGF-β Receptor TGF-beta/Smad Interleukin Related

Mogroside III-E is a cucurbitane-type triterpenoid glycoside extracted from Siraitia grosvenorii, and it is an orally active TLR4 inhibitor. Mogroside III-E downregulates the expression of TLR4 and MyD88, and blocks the phosphorylation of downstream ERK, JNK and p38 MAPK molecules; meanwhile, it inhibits TGF-β- or LPS-mediated transdifferentiation of primary pulmonary fibroblasts into myofibroblasts, reduces the content of fibrosis markers such as hydroxyproline, suppresses the pro-fibrotic TGF-β/Smad signaling pathway, and downregulates the levels of inflammatory factors MPO and IL-1β. Mogroside III-E alleviates Bleomycin (HY-108345)-induced pulmonary collagen deposition and inflammatory infiltration in mice. Mogroside III-E can be used in studies related to idiopathic pulmonary fibrosis .
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Mogroside III-E (Standard)
Mogroside III-E (Standard)
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Cat. No.: HY-N6928R
CAS No.: 88901-37-5
Category:  

Triterpenes Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants

Target:  

Toll-like Receptor (TLR) Reference Standards

Mogroside III-E (Standard) is the analytical standard of Mogroside III-E. This product is intended for research and analytical applications. Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, inhibits NO release, with anti-fibrotic activity .
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