7 Results for "

Monosodium urate

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "Monosodium urate" in MCE Product Catalog:

  • Targets Recommended:
22
Uric acid sodium
Uric acid sodium
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22 Publications Verification
Cat. No.: HY-B2130A
CAS No.: 1198-77-2
Synonyms: Monosodium urate
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Reactive Oxygen Species (ROS)

Uric acid sodium is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid sodium can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid sodium can be used as a modeling agent in research on hyperuricemia-induced hypertension models .
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2
(Z)-Aconitic acid
(Z)-Aconitic acid
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2 Cited Publications
Cat. No.: HY-W016814
CAS No.: 585-84-2
Synonyms: cis-Aconitic acid
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Amino Acid Decarboxylase

(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .
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2
Cichoriin
Cichoriin
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2 Cited Publications
Cat. No.: HY-N8599
CAS No.: 531-58-8
Category:  

Infection other families Monophenols Coumarins Phenols Phenylpropanoids Plants Disease Research Fields

Target:  

Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB

Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .
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1
Britannin
Britannin
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1 Cited Publications
Cat. No.: HY-N3005
CAS No.: 33627-28-0
Category:  

Phyllodium pulchellum (L.) Desv. Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis

Britannin is an NLRP3 inhibitor with an IC50 of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .
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(Z)-Aconitic acid (Standard)
(Z)-Aconitic acid (Standard)
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Cat. No.: HY-W016814R
CAS No.: 585-84-2
Synonyms: cis-Aconitic acid (Standard)
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite

(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .
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Uric acid sodium (Standard)
Uric acid sodium (Standard)
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Cat. No.: HY-B2130AR
CAS No.: 1198-77-2
Synonyms: Monosodium urate (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Reactive Oxygen Species (ROS) Endogenous Metabolite Reference Standards

Uric acid sodium (Standard) (Monosodium urate (Standard)) is the analytical standard of Uric acid sodium (HY-B2130A). This product is intended for research and analytical applications. Uric acid sodium is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid sodium can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid sodium can be used as a modeling agent in research on hyperuricemia-induced hypertension models .
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ODZ10117
ODZ10117
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Cat. No.: HY-182380
CAS No.: 1632152-27-2
Target:  

STAT NOD-like Receptor (NLR) Apoptosis

Research Areas:  

Others Neurological Disease Inflammation/Immunology Cancer

ODZ10117 is a STAT3 and NLRP3 inhibitor with a human STAT3 SH2 domain IC50 of 7.5 μM. ODZ10117 binds to the STAT3 SH2 domain, suppressing tyrosine phosphorylation, dimerization, nuclear translocation, and transcriptional activity. ODZ10117 binds to NLRP3, impairs NEK7 interaction, prevents inflammasome formation, and inhibits caspase-1 and IL-1β cleavage.ODZ10117 reduces MSU (HY-B2130A)-induced IL-1β release, lowers LPS (HY-D1056)-induced sepsis mortality, and exhibits anti-inflammatory effects. ODZ10117 induces apoptosis, suppresses breast cancer cell migration and invasion, reduces tumor growth and lung metastasis, and extends survival in breast cancer models. ODZ10117 can be used for the research of Monosodium urate (HY-B2130A)-induced peritonitis, LPS-induced sepsis, breast cancer, glioblastoma, and Alzheimer's disease .
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