531-58-8
Chemical Structure
Cichoriin
- CAS No.: 531-58-8
- Formula:C15H16O9
- Molecular Weight:340.28
IUPAC Name: 6-hydroxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
InChIKey: WNBCMONIPIJTSB-TVKJYDDYSA-N
SMILES: OC1=C(C=C2C(C=CC(O2)=O)=C1)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
Biological Activity: Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cichoriin | 99.9% | Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2. | ||||||||||||||||||||
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References
- [1]. Sishu NK, et al. Cichoriin, a coumarin glycoside with antidiabetic effect and cardioprotective activity against H2O2 induced oxidative stress in H9c2 cells: in-vitro and in-silico study. Free Radic Biol Med. 2025;241:671-688. [Content Brief]
- [2]. Khalil HE, et al. Cichoriin, a Biocoumarin, Mitigates Oxidative Stress and Associated Adverse Dysfunctions on High-Fat Diet-Induced Obesity in Rats. Life (Basel). 2022;12(11):1731. Published 2022 Oct 28. [Content Brief]
- [3]. Zhao Y, et al. Cichoriin suppresses hepatic lipid accumulation and fibrosis in mice metabolic dysfunction associated steatohepatitis via the AMPK pathway. Biochem Pharmacol. 2026;245:117630. [Content Brief]
- [4]. Rivero-Segura NA, et al. In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19. Biomolecules. 2021;11(2):216. Published 2021 Feb 4. [Content Brief]
