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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
NAD biosynthesis
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "NAD biosynthesis" in MCE Product Catalog:
1
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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1
1 Cited Publications
Cat. No.: HY-128700A
Purity: 98.28%
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Nicotinic acid mononucleotide triethylamine acts as a SARM1 inhibitor and a NAD + biosynthesis intermediate, with an IC50 value of 93.3 μM against SARM1. Nicotinic acid mononucleotide triethylamine exerts axon-protective effects, delays axonal degeneration, elevates NAD + levels, enhances Sirt1 activity, improves myocardial capillary density and alleviates myocardial fibrosis. Nicotinic acid mononucleotide triethylamine reverses diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD + levels. Nicotinic acid mononucleotide triethylamine is applicable to research related to cancer, multiple sclerosis, diabetic cardiomyopathy, neurodegenerative diseases and Huntington's disease .
Cat. No.: HY-W013046
CAS No.: 108321-05-7
Synonyms: PRPP pentasodium
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Cat. No.: HY-E70020
UDP-Glc dehydrogenase (UGDH) catalyzes is a NAD+-dependent enzyme that catalyzes the two-fold oxidation of UDP-glucose (UDP-Glc) to produce UDP-glucuronic acid. UDP-Glc dehydrogenase (UGDH) is a key enzyme in the nucleotide-sugar interconversion pathway necessary for biosynthesis of many cell-wall polysaccharides .
Cat. No.: HY-162269
CAS No.: 3041005-21-1
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Nampt activator-5 is a NAMPT activator with a KD value of 6.19 μM. Nampt activator-5 activates the rate-limiting enzyme in NAD + biosynthesis and promotes NAD + production. Nampt activator-5 delays the senescence process of senescent hepatocytes, extends the lifespan of *Caenorhabditis elegans*, and alleviates age-related dysfunction and abnormal biomarkers in naturally aged mice. Nampt activator-5 can be used in aging research .
Cat. No.: HY-148572
CAS No.: 2247884-06-4
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NAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and IDO1 with IC50s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel .
Cat. No.: HY-184467
CAS No.: 1362150-16-0
Nampt-IN-20 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor with a IC50 of 9.0 nM. Nampt-IN-20 binds to the active site of Nampt, occupies the NAM-binding region and disrupts NAD biosynthesis. Nampt-IN-20 exerts antiproliferative effects in A2780 ovarian cancer cells. Nampt-IN-20 can be used for the research of ovarian cancer .
Cat. No.: HY-E71411
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2,3-bis-O-Geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H] (EC 1.3.1.101) participates in the biosynthesis of membrane lipids, producing 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate.
Cat. No.: HY-E71512
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2-Dehydropantoate 2-reductase (EC 1.1.1.169) belongs to the oxidoreductase family, which refers to oxidoreductases that use NAD+ or NADP+ as acceptors and act on the CH-OH group as donors. 2-Dehydropantoate 2-reductase (EC 1.1.1.169) participates in the biosynthesis of pantothenic acid and coenzyme A.
Cat. No.: HY-E71001
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L-Leucine Dehydrogenase, Bacillus cereus (EC 1.4.1.9) is a redox enzyme that acts on the donor CH-NH2 group and uses NAD+ or NADP+ as the acceptor. L-Leucine Dehydrogenase, Bacillus cereus (EC 1.4.1.9) participates in the degradation of valine, leucine, and isoleucine, as well as their biosynthesis.
Cat. No.: HY-E71416
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2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase (EC 1.3.1.28) belongs to the family of oxidoreductases that act on the CH-CH group of donors, using NAD+ or NADP+ as an acceptor. 2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase is involved in the biosynthesis of non-ribosomal siderophores.
Cat. No.: HY-183148
CAS No.: 2237269-22-4
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NAMPT activator-10 (Compound B11) is an orally active NAMPT activator with a target Kd value of 0.64 μM. NAMPT activator-10 activates the rate-limiting enzyme in NAD + biosynthesis and promotes intracellular NAD + synthesis. NAMPT activator-10 reduces lactate accumulation, enhances glycogen storage in the liver and muscle, increases tissue ATP production, improves exercise endurance and muscle strength, and exerts a protective effect against fatigue-induced muscle damage in mouse fatigue models. NAMPT activator-10 can be used in studies related to muscle fatigue .
Cat. No.: HY-179523
CAS No.: 2635394-10-2
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Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN) .
Cat. No.: HY-182567
CAS No.: 2109805-79-8
Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human Ki of 5.6 nM. Nampt-IN-19 blocks NAD + biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer .
Cat. No.: HY-E71528
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2-epi-5-epi-Valiolone synthase (EC 4.2.3.152) exhibits high specificity for α-D-sedaripogonanone-7-phosphate. 2-epi-5-epi-Valiolone synthase (EC 4.2.3.152) requires a divalent metal ion (Zn2+ or Co2+) and a NAD+ cofactor, the latter of which is transiently reduced during the reaction. 2-epi-5-epi-Valiolone synthase (EC 4.2.3.152) participates in the biosynthesis of C7N-aminocyclic alcohols.
Cat. No.: HY-184918
CAS No.: 3097045-01-4
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NAMPT/PD-1/PD-L1-IN-1 is a potent the PD-1/PD-L1 interaction and NAMPT dual inhibitor with IC50s of 7.5 nM and 18.8 nM, respectively. NAMPT/PD-1/PD-L1-IN-1 enhances T cell-mediated tumor cell killing, promotes T cell proliferation and CD8 + T cell proportion and depletes intracellular NAD + biosynthesis. NAMPT/PD-1/PD-L1-IN-1 suppresses tumor progression in a mouse LLC xenograft model by disrupting tumor metabolism and activating the tumor immune microenvironment. NAMPT/PD-1/PD-L1-IN-1 can be used in research on tumor immunotherapy for non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
