2109805-79-8
Chemical Structure
Nampt-IN-19
- CAS No.: 2109805-79-8
- Formula:C25H31N3O3
- Molecular Weight:421.53
InChIKey: GBPFJQPCQMDAAN-UHFFFAOYSA-N
SMILES: O=C(N1CC2=C(C1)C=CC=C2)NC3=CC=C(C4CCN(CC4)C(CC(C)(C)O)=O)C=C3
Biological Activity: Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human Ki of 5.6 nM. Nampt-IN-19 blocks NAD+ biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer[1].
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Nampt-IN-19 | Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human Ki of 5.6 nM. Nampt-IN-19 blocks NAD+ biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer. | |||||||||||||||||||||
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Keywords
